Lymphocyte 5′-Nucleotidase Deficiency: Clinical and Metabolic Characteristics of the Associated Hypogammaglobulinemia
Decreased activity of 5′-nucleotidase on the surface of peripheral blood mononuclear cells (PBM’s) has recently been observed in young males with congenital agammaglobulinemia1, primary non-familial hypogammaglobulinemia1–3, and selective IgA deficiency3,4. A partial deficiency of the ecto-enzyme occurred in 12 of 12 patients with congenital agammaglobulinemia, in 4 of 15 with acquired (common variable) immunodeficiency, and in 2 of 10 with selective IgA deficiency. The enzyme values and clinical classification of the 18 enzyme deficient subjects with primary hypogammaglobulinemia are shown in Table 1.
KeywordsCarbonyl Iron Purine Metabolism Common Variable Immunodeficiency Nucleotidase Activity Peripheral Mononuclear Cell
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