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Suppression of Cellular Immunity due to Inhibition of Purine Nucleoside Phosphorylase by Allopurinol-Riboside

  • Y. Nishida
  • N. Kamatani
  • K. Tanimoto
  • I. Akaoka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

Recently, children with purine nucleoside Phosphorylase (PNP) deficiency have been reported to show defective T cell immunity but intact B cell immunity (1). These findings suggest that inhibition of PNP may result in suppression of T cell functions and an inhibitor of PNP may also be a useful immunosuppressive agent.

Keywords

Xanthine Oxidase Cellular Immunity Purine Nucleoside Phosphorylase Glass Fiber Filter Paper Physical Therapy Faculty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Giblett, E.R. et al Lancet 1: 1010, 1975PubMedCrossRefGoogle Scholar
  2. 2.
    Kalcker H.M. J. Biol.Chem. 167: 429, 1947Google Scholar
  3. 3.
    Boyum, A. Scand. J. Clin. Lab. Invest 21: 77, 1968.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Y. Nishida
    • 1
  • N. Kamatani
    • 1
  • K. Tanimoto
    • 1
  • I. Akaoka
    • 1
  1. 1.Department of Medicine and Physical Therapy Faculty of MedicineUniversity of TokyoBunkyo-ku, TokyoJapan

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