Suppression of Cellular Immunity due to Inhibition of Purine Nucleoside Phosphorylase by Allopurinol-Riboside
Recently, children with purine nucleoside Phosphorylase (PNP) deficiency have been reported to show defective T cell immunity but intact B cell immunity (1). These findings suggest that inhibition of PNP may result in suppression of T cell functions and an inhibitor of PNP may also be a useful immunosuppressive agent.
KeywordsXanthine Oxidase Cellular Immunity Purine Nucleoside Phosphorylase Glass Fiber Filter Paper Physical Therapy Faculty
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