Cyclic Nucleotide Levels and Mechanism of Inhibition of Leucocyte Function by Adenosine Deaminase Inhibition
The association of adenosine deaminase (ADA) deficiency and severe combined immunodeficiency syndrome has focused attention upon purine metabolism as a modulator of the immune response (1–3). In in vitro studies, adenosine deaminase appears to be necessary for normal lymphocyte blastogenesis in response to phytomitogens and for mononuclear cell maturation (4–6). Various mechanisms of potential cellular toxicity have been proposed including accumulation of adenosine (4, 5), pyrmidine starvation (7, 8), accumulation of deoxyadenosine (9), inhibition of S-adenosylmethionine (SAM) dependent methylation reactions (10), and accumulation of intracellular cyclic AMP (4, 11).
KeywordsAdenosine Deaminase Purine Metabolism Lymphocyte Blastogenesis Adenosine Deaminase Deficiency Cyclic Nucleotide Level
Unable to display preview. Download preview PDF.
- 12.A. D. Meisel, C. Natarajan, G. Sterba, and H. S. Diamond, Effect of adenosine deaminase inhibition on leucocyte function, Clin. Res. 27:331A (1979).Google Scholar
- 13.A. Boyum, Separation of leukocytes from blood and bone marrow, Scand. J. Clin. Lab. Invest. 21:Suppl. 97, 77 (1968).Google Scholar
- 15.G. Marone, M. Plaut, and L. M. Lichtenstein, Characterization of a specific adenosine receptor on human lymphocytes, J. Immunol. 11:2153 (1978).Google Scholar