Effect of Allopurinol on Pyrimidine Metabolism in Human White Blood Cells. Role of the Salvage Pathway
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)
The administration of allopurinol leads to an increase of urinary excretion of orotic acid and orotidine (Fox et al. 197o) due to an inhibition of orotidine-5-phosphate decarboxylase (ODC).
KeywordsSerum Uric Acid Salvage Pathway Orotic Acid Pyrimidine Metabolism Pyrimidine Synthesis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Unable to display preview. Download preview PDF.
- Becker, M. A., Kent, F. A., Fox, R. M., and Seegmiller, E., 1974, Oxipurinol Assoziated Inhibition of Pyrimidine Synthesis in Human Lymphoblasts, Molec. Pharm., l0:657.Google Scholar
© Plenum Press, New York 1980