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Regulatory Properties of AMP Deaminase Isozymes

  • Nobuaki Ogasawara
  • Haruko Goto
  • Yasukazu Yamada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

AMP deaminase catalyzes the deamination of AMP to form IMP and ammonia. The function of AMP deaminase in cellular metaholism remains obscure, but a number of physiological roles have been proposed. The enzyme may be responsible for the conversion of adenine nucleotide to inosine or guanine nucleotide1, for stabilizing the adenylate energy charge2, and the reaction of the purine nucleotide cycle3.

Keywords

Monovalent Cation Energy Charge Adenylate Kinase Adenylate Energy Charge Isozyme Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A. Askari and S. N. Rao, Regulation of AMP deaminase by 2,3-diphosphoglyceric acid: A possible mechanism for the control of adenine nucleotide metabolism in human erythrocytes, Biochim. Biophys. Acta, 151:198 (1968).CrossRefGoogle Scholar
  2. 2.
    A. G. Chapman and D. E. Atkinson, Stabilization of adenylate energy charge by adenylate deaminase reaction, J. Biol. Chem., 248:8309 (1973).PubMedGoogle Scholar
  3. 3.
    J. M. Lowenstein, Ammonia production in muscle and other tissues: The purine nucleotide cycle, Physiol. Rev., 52:382 (1972).Google Scholar
  4. 4.
    N. Ogasawara, H. Goto, Y. Yamada and M. Yoshino, Subunit structures of AMP deaminase isozymes in rat, Biochem. Biophys. Res. Commun., 79:671 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    N. Ogasawara, H. Goto and T. Watanabe, Isozymes of rat AMP deaminase, Biochim. Biophys. Acta, 403:530 (1975).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Nobuaki Ogasawara
    • 1
  • Haruko Goto
    • 1
  • Yasukazu Yamada
    • 1
  1. 1.Department of BiochemistryInstitute for Developmental ResearchAichi Prefectural Colony, Kasugai, AichiJapan

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