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Radioimmunochemical Analysis of Human Erythrocyte Adenosine Deaminase

  • Peter E. Daddona
  • Michael A. Frohman
  • William N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

Adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4.) catalyzes the irreversible hydrolytic deamination of adenosine to produce inosine and ammonia. Markedly reduced or absent adenosine deaminase activity in man is associated with an autosomal recessive form of severe combined immunodeficiency disease and the relationship appears to be causal.1,2,3,4 Affected patients present a defect of both cellular and humoral immunity characterized clinically by severe recurrent infections with a uniformly fatal outcome if untreated.

Keywords

Adenosine Deaminase Severe Combine Immunodeficiency Severe Combine Immunodeficiency Disease Autosomal Recessive Form Amniotic Fluid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Peter E. Daddona
    • 1
  • Michael A. Frohman
    • 1
  • William N. Kelley
    • 1
  1. 1.Departments of Internal Medicine and Biological Chemistry, Human Purine Research CenterUniversity of Michigan Medical SchoolAnn ArborUSA

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