Adenosine and Deoxyadenosine Kinase from Rat Liver
Recent studies demonstrated that dATP concentration was markedly increased in erythrocytes from patient with adenosine deaminase deficiency1,2 . Deoxyadenosine is toxic to T lymphoblast in the presence of an inhibitor of adenosine deaminase. By the addition of deoxyadenosine, dATP accumulated in the cell and the level of dATP well corelated with the cytotoxicity4,5.
KeywordsKinase Activity Pyruvate Kinase Adenosine Deaminase Severe Combine Immunodeficiency NADH Oxidation
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