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Chemical Modification of Hypoxanthine-Phosphoribosyltransferase and Its Protection by Substrates and Products

  • Wolf Gutensohn
  • Heidi Jahn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

The importance of hypoxanthine-phosphoribosyltransferase (HPRT) to human biochemical genetics need not be stressed in this context. Although in some cases it has not been clear whether deficiencies of this enzyme are due to a structural mutation this seems to be well established in others. Hence a detailed knowledge of the structure and especially of essential amino acid residues seems desirable. Induced by a similar study on quinolinate-phosphoribosyltransferase1 and parallel to our experiments on specific irreversible inhibition chemical modification of HPRT was investigated.

Keywords

Methylene Blue Sulfonic Acid Quinolinic Acid Purine Nucleoside Structural Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Wolf Gutensohn
    • 1
  • Heidi Jahn
    • 1
  1. 1.Arbeitsgruppe Biochemische HumangenetikInstitut für Anthropologie und Humangenetik UniversitätMünchen 2Fed.Rep.Germany

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