Chemical Modification of Hypoxanthine-Phosphoribosyltransferase and Its Protection by Substrates and Products

  • Wolf Gutensohn
  • Heidi Jahn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)


The importance of hypoxanthine-phosphoribosyltransferase (HPRT) to human biochemical genetics need not be stressed in this context. Although in some cases it has not been clear whether deficiencies of this enzyme are due to a structural mutation this seems to be well established in others. Hence a detailed knowledge of the structure and especially of essential amino acid residues seems desirable. Induced by a similar study on quinolinate-phosphoribosyltransferase1 and parallel to our experiments on specific irreversible inhibition chemical modification of HPRT was investigated.


Methylene Blue Sulfonic Acid Quinolinic Acid Purine Nucleoside Structural Mutation 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Wolf Gutensohn
    • 1
  • Heidi Jahn
    • 1
  1. 1.Arbeitsgruppe Biochemische HumangenetikInstitut für Anthropologie und Humangenetik UniversitätMünchen 2Fed.Rep.Germany

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