Purification and Characterization of Mammalian Adenine Phosphoribosyltransferases

  • Milton W. Taylor
  • Howard V. Hershey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)


In mammals, the enzyme adenine phosphoribosyl transferase (APRT; AMP: pyrophosphate phosphoribosyl transferase; E.C. 2·42·7) is the only known mechanism by which dietary adenine can be utilized1. In humans with reduced or absent APRT activity, renal stones containing substantial amounts of 2,8-dioxyadenine can occur1. However, other APRT deficient individuals do not suffer urolithiasis and appear to be asymptomatic. Thus, the role of APRT, and, indeed, the role of adenine, in the metabolism of mammals is unclear.


Human Erythrocyte Syrian Hamster Phosphoribosyl Transferase Electrophoretic Variant Pyrophosphate Phosphoribosyl 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Milton W. Taylor
    • 1
  • Howard V. Hershey
    • 1
  1. 1.Department of BiologyIndiana UniversityBloomingtonUSA

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