Purification and Characterization of Mammalian Adenine Phosphoribosyltransferases
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 122B)
In mammals, the enzyme adenine phosphoribosyl transferase (APRT; AMP: pyrophosphate phosphoribosyl transferase; E.C. 2·42·7) is the only known mechanism by which dietary adenine can be utilized1. In humans with reduced or absent APRT activity, renal stones containing substantial amounts of 2,8-dioxyadenine can occur1. However, other APRT deficient individuals do not suffer urolithiasis and appear to be asymptomatic. Thus, the role of APRT, and, indeed, the role of adenine, in the metabolism of mammals is unclear.
KeywordsHuman Erythrocyte Syrian Hamster Phosphoribosyl Transferase Electrophoretic Variant Pyrophosphate Phosphoribosyl
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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