Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)
Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Nucleotide Interconversion
It is well established that human Hypoxanthine-Guanine Phospho-ribosyltransferase (HGPRT, EC 184.108.40.206) catalyzes the reactions:
KeywordsXanthine Oxidase Steady State Kinetic Hypoxanthine Guanine Phosphoribosyltransferase Irreversible Step Lesch Nyhan Syndrome
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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- 2.J.B. Wyngaarden and W.N. Kelley, “Gout and hyperuricemia”, Grune & Stratton, New York (1976).Google Scholar
- 9.H.M. Kalckar, Differential spectrophotometry of purine compounds by means of specific enzymes, J. Biol. Chem. 167: 42 8(1947).Google Scholar
- 10.M. Grassl, Guanosine-5′-monophosphate, in “Methods of enzymatic analysis”, H.U. Bergmeyer ed., Academic Press, New York (1974)Google Scholar
- 11.R.B. Huribert, H. Schmitz, A.F. Brumm, V.R. Potter, Chromatographic separation of acid soluble nucleotides, J. Biol. Chem. 209: 23 (1954)Google Scholar
- 15.C. Salerno and A. Giacomello, Human hypoxanthine guanine phosphoribosyltransferase — IMP-GMP exchange: stoichiometry and steady state kinetics of the reaction, in press.Google Scholar
- l6.I.H. Segel, “Enzyme kinetics — behaviour and analysis of rapid equilibrium and steady state enzyme systems”, J. Wiley & Sons New York (1975).Google Scholar
© Plenum Press, New York 1980