Uptake of Adenosine in Human Erythrocytes

  • M. Kraupp
  • P. Chiba
  • M. M. Müller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)


The transport of nucleosides across mammalian cell membranes is performed by a transport system with broad specificity for purine and pyrimidine nucleosides, For this uptake process a two comnonent system is discussed; one for low physiological and another for high concentrations of nucleosides (1, 2, 3). In human blood platelets a close association of the high affinity carrier for adenosine with adenosine kinase (AK, E. C. was postulated, indicating phosphorylation being an integral part of adenosine transport as described in bacteria (3, 4). In contrast at high concentrations adenosine transported unchanged into the platelets and is then converted by adenosine deaminase (ADA, E. C. and purine nucleoside Phosphorylase (PNP, E. C. into inosine and hypoxanthine.


Incubation Medium Human Erythrocyte Adenosine Deaminase Uptake Process Purine Nucleoside Phosphorylase 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • M. Kraupp
    • 1
  • P. Chiba
    • 1
  • M. M. Müller
    • 1
  1. 1.Department of Medical Chemistry and 2nd Department of MedicineUniversity of ViennaAustria

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