Regulation of Purine Savage Enzymes in E. coli
There is no doubt that in eukaryotic cells there is an interplay between the de novo purine biosynthetic pathway and purine salvage enzymes, or products of these enzymes. Feedback inhibition of the first specific enzyme of the pathway, PRPP amidotransferase, occurs via AMP or GMP and repression of the pathway is possibly controlled by the product of the salvage enzymes, APRT and HGPRT (Henderson, 1972).
KeywordsAdenosine Deaminase Purine Metabolism Purine Base Purine Biosynthesis Fold Stimulation
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