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Purine Salvage Enzymes in Man and Leishmania donovani

  • Thomas A. Krenitsky
  • George W. Koszalka
  • Joel V. Tuttle
  • David L. Adamczyk
  • Gertrude B. Elion
  • J. Joseph Marr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

A comparison of the enzymes of pathogenic protozoa to those of man is of fundamental importance to the search for much needed chemotherapeutic agents. The enzymes involved in purine salvage are of particular interest because most pathogenic protozoa lack the ability to synthesize purines de novo and consequently are obligate salvagers of preformed purines.

Keywords

Thymidine Kinase Adenosine Deaminase Purine Nucleoside Aldehyde Oxidase Purine Nucleoside Phosphorylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Thomas A. Krenitsky
    • 1
  • George W. Koszalka
    • 1
  • Joel V. Tuttle
    • 1
  • David L. Adamczyk
    • 1
  • Gertrude B. Elion
    • 1
  • J. Joseph Marr
    • 2
  1. 1.Wellcome Research Labs.USA
  2. 2.St. Louis University School of MedicineSt. LouisUSA

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