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Immunological Stress Induces Severe Cardiac Myolysis: Mediation by Leukotrienes

  • U. Zor
  • S. Moshonov
  • A. Meshorer
  • N. Kauli
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

In this review we bring evidence that immunological stress can lead directly to severe cardiac myolysis, which in turn could result in acute myocardial infarction (AMI). This kind of stress results from the reaction following antigen-antibody (Ag-Ab) complex formation on various cell surfaces. The chain of events includes an increase in intracellular Ca2+ concentration in certain cells which results in leukotriene (LT) generation. Leukotrienes are the principal mediators of anaphylatic shock, and cardiac anaphylaxis. A possible mechanism by which psychological (emotional) stress causes AMI will also be discussed. This is based on the hypothesis that stress-induced neurotransmitter release (acetylcholine, noradrenaline, dopamine) can stimulate LT production in the heart.

Keywords

Acute Myocardial Infarction Acute Myocardial Infarction Vesicular Stomatitis Virus Coronary Vasculature Immunological Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W.C. Roberts and B. M. Buja, The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction, Am. J. Med. 52:425 (1974).CrossRefGoogle Scholar
  2. 2.
    H.R. Hellstrom, Coronary artery vasospasm: the likely immediate cause of acute myocardial infarction, Br. HeartJ. 41:426 (1979).CrossRefGoogle Scholar
  3. 3.
    C.D. Jenkins, Recent evidence supporting psychologic and social risk factors for coronary disease, NewEng. J. ofMed. 294:987 (1976).CrossRefGoogle Scholar
  4. 4.
    P.J. Piper, Pharmacology of leukotrienes, Brit. Med. Bull. 39:255 (1933).Google Scholar
  5. 5.
    G. Feuerstein, Leukotrienes and the cardiovascular system, Prostaglandins 27:731 (1984).Google Scholar
  6. 6.
    R. Levi, J.A. Burke and E.J. Corey, SRS-A, leukotrienes, and immediate hypersensitivity reactions of the heart, in: “Leukotrienes and Other Lipoxygenase Products”, B. Samuelsson and R. Paoletti, eds., Raven Press, New York, pp. 215–222 (1982).Google Scholar
  7. 7.
    B. Samuelsson, Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation, Science 220:568 (1983).PubMedCrossRefGoogle Scholar
  8. 8.
    C.L. Miklozek and W.H. Abelmann, Viral myopericarditis presenting as acute myocardial infarction, Circulation 64:IV-25 (1982).Google Scholar
  9. 9.
    D.H. Spodick, A.P. Flessas and M.M. Johnson, Association of acute respiratory symptoms with onset of acute myocardial infarction: prospective investigation of 150 consecutive patients and matched control patients, Am. J. Cardiol. 53:481 (1984).PubMedCrossRefGoogle Scholar
  10. 10.
    D. Bainton, G.R. Jones and D. Hole, Influenza and ischaemic heart disease—a possible trigger for acute myocardial infarction? Intl. J. Epidemiology 7:231 (1973).CrossRefGoogle Scholar
  11. 11.
    M.J. Schlesinger and L. Reiner, Focal myocytolysis of the heart, Amer. J. Pathol. 31:443 (1955).Google Scholar
  12. 12.
    K.M. Mullane, N. Read, J.A. Salmon, and S. Moncada, Role of leukocytes in acute myocardial infarction in anesthetized dogs: Relationship to myocardial salvage by anti-inflammatory drugs, J. Pharm. Exp. Ther. 228:510 (1984).Google Scholar
  13. 13.
    J.L. Romson, B.G. Hook, S.L. Kunkel, G.D. Abrams, M.A. Schork, and B.R. Lucchesi, Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog, Circulation 67:1016 (1983).PubMedCrossRefGoogle Scholar
  14. 14.
    P. Andersson, Effects of inhibitors of anaphylactic mediators in two models of bronchial anaphylaxis in anaesthetized guinea-pigs, Br. J. Pharmac. 77:301 (1982).CrossRefGoogle Scholar
  15. 15.
    P. Libby, P.R. Maroko, C.M. Bloor, B.E. Sobel and E. Braunwald, Reduction of experimental myocardial infarct size by corticosterone administration, JClin. Invest. 52:599 (1973).CrossRefGoogle Scholar
  16. 16.
    W.P. Newman III, R.E. Tracy, J.P. Strong, W.D. Johnson and M.C. Oalmann, Pathology of sudden coronary death, Ann. N.Y. Acad. Sci. 382:39 (1982).PubMedCrossRefGoogle Scholar
  17. 17.
    R.S. Eliot and J.C. Buell, Role of the central nervous system in sudden cardiac death, In: “Biobehavioral Bases of Coronary Heart Disease”, T.M. Dernbroski, T.H. Schmidt, G. Blümchen, eds., S. Karger, Basel pp. 257–270 (1983).Google Scholar
  18. 18.
    J.C. Buell and R.S. Eliot, Behavior and the pathophysiology of coronary heart disease in humans, in: “Biobehavioral Bases of Coronary Heart Disease”, T.M. Dernbroski, T.H. Schmidt, G. Blümchen, eds., S. Karger, Basel pp. 237–247 (1983).Google Scholar
  19. 19.
    D. Trichopoulos, K. Katsouyanni, X. Zavitsanos, A. Tzonou and P. Dalla-Vorgia, Psychological stress and fatal heart attack: The Athens (1981) earthquake natural experiment. The Lancet, February 26, 441 (1983).CrossRefGoogle Scholar
  20. 20.
    S.F. Vatner, Alpha-adrenergio regulation of the coronary circulation in the conscious dog. Am. J. ofCardiol. 52:15A (1933).CrossRefGoogle Scholar
  21. 21.
    S. Anir, Anti-anaphylactie action in the mouse of thyrotropin-releasing hormone (TRH) is mediated through β1-adrenoceptiveGoogle Scholar
  22. 22.
    H. Yasue, M. Touyama, M. Shimamoto, H. Kato, S. Tanaka and F. Akiyama, Role of autonomie nervous system in the pathogenesis of Prinzmetal’s variant form of angina, Circulation 50:534 (1974).PubMedCrossRefGoogle Scholar
  23. 23.
    A.A. Abdel-Latif, J.P. Smith, S.Y.K. Yousufzai and R.K. Dover, Effects of catecholamines and their metabolites and other pharmacological agents on arachidonic acid metabolism and prostaglandin release by rabbit iris muscle and iris microsomes, in: “Neural Membranes”, G.Y. Sun, N. Bazan, J-Y Wu, G. Porcellati and A.Y. Sun, eds., The Humana Press, Inc., Clifton, N.J. pp. 97–122 (1933).Google Scholar
  24. 24.
    M. Kaliner, R.P. Orange and F.K. Austen, Immunological release of histamine and slow reacting substance of anaphylaxis from human lung, J. Exp. Med. 136:556 (1972).PubMedCrossRefGoogle Scholar
  25. 25.
    D.I. Alexander, P. Eyre and V.P. Gordon, Anaphylactic contraction (Schultz-Dale reaction) of the bovine bronchial artery in vitro, Br. J. Pharmac. 80:7 (1983).CrossRefGoogle Scholar
  26. 26.
    S. Bongrani, G.C. Folco, R. Razzetti and P. Schiantarelli, β2-adrenoceptor blockade is the basis of guinea-pig bronchial hyper-responsiveness to leukotriene C4 and other agonists, Br. J. Pharmac. 79:839 (1983).CrossRefGoogle Scholar
  27. 27.
    T. Kirchner and B.M. Weichman, Propranolol potentiates leukotriene D4-induced bronchoconstriction and enhances antagonism by FPL 55712, Prostaglandins 27:119 (1984).PubMedGoogle Scholar
  28. 28.
    B.A. Berkowitz, Dopamine and dopamine receptors as target sites for cardiovascular drug action, Fed. Proc. 42:3019 (1933).Google Scholar
  29. 29.
    M. Endo, K. Hirosawa, N. Kaneko, K. Hase, Y. Inoue and S. Konno, Prinzmetal’s variant angina. Coronary arteriogram and left ventriculogram during angina attack induced by methacholine, NewEng. J. ofMed. Jan. 294:252 (1976).Google Scholar
  30. 30.
    U. Förstermann and B. Neufang, C-6-sulfidopeptide luekotrienes are unlikely to be involved in the endothelium dependent relaxation of rabbit aorta by acetylcholine, Prostaglandins 27:181 (1984).PubMedCrossRefGoogle Scholar
  31. 31.
    M. Halonen and M. Kaliner, Heightened cholinergic responsiveness in IgE-producing rabbits, Int. J. Immunopharmac. 6:351 (1984).CrossRefGoogle Scholar
  32. 32.
    R. Fantozzi, E. Masini, P. Blandina, P.F. Mannaioni and T. Bani-Sacchi, Release of histamine from rat mast cells by acetylcholine, Nature 273:473 (1973).CrossRefGoogle Scholar
  33. 33.
    L.H. Criep and T.R. Woehler, The heart in human anaphylaxis, AnnofAllergy 29:399 (1971).Google Scholar
  34. 34.
    J. Heikkilä, and J. Karjalainen, Evaluation of mild acute infectious myocarditis, Br. HeartJ. 47:381 (1982).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • U. Zor
    • 1
  • S. Moshonov
    • 1
  • A. Meshorer
    • 2
  • N. Kauli
    • 3
  1. 1.Dept. of Hormone ResearchThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Dept. of Experimental AnimalsThe Weizmann Institute of ScienceRehovotIsrael
  3. 3.Heart InstituteKaplan HospitalRehovotIsrael

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