Immunological Stress Induces Severe Cardiac Myolysis: Mediation by Leukotrienes

  • U. Zor
  • S. Moshonov
  • A. Meshorer
  • N. Kauli
Part of the Biochemical Endocrinology book series (BIOEND)


In this review we bring evidence that immunological stress can lead directly to severe cardiac myolysis, which in turn could result in acute myocardial infarction (AMI). This kind of stress results from the reaction following antigen-antibody (Ag-Ab) complex formation on various cell surfaces. The chain of events includes an increase in intracellular Ca2+ concentration in certain cells which results in leukotriene (LT) generation. Leukotrienes are the principal mediators of anaphylatic shock, and cardiac anaphylaxis. A possible mechanism by which psychological (emotional) stress causes AMI will also be discussed. This is based on the hypothesis that stress-induced neurotransmitter release (acetylcholine, noradrenaline, dopamine) can stimulate LT production in the heart.


Acute Myocardial Infarction Acute Myocardial Infarction Vesicular Stomatitis Virus Coronary Vasculature Immunological Stress 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • U. Zor
    • 1
  • S. Moshonov
    • 1
  • A. Meshorer
    • 2
  • N. Kauli
    • 3
  1. 1.Dept. of Hormone ResearchThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Dept. of Experimental AnimalsThe Weizmann Institute of ScienceRehovotIsrael
  3. 3.Heart InstituteKaplan HospitalRehovotIsrael

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