Modified Development of the Hypothalamo-Pituitary-Adrenocortical (HPA) Axis Response to Stress in Young Rodents with Experimentally Altered Thyroid Status
The study of development of the stress-adaptive hypothalamo-pituitary-adrenocortical (HPA) axis in young rodents is of interest because of the considerable degree of maturation which occurs postnatally. When first described by Schapiro et al. (1962), the so-called stress non-responsive (SNR) period was felt to be absolute, with the HPA axis of rats unable to respond to a stress between approximately postnatal days 3 and 12. With the advancement of technological methods it has been demonstrated that the SNR period is relative rather than absolute, and that HPA axis response during this time is dampened rather than prevented (Schoenfeld et al., 1980; Milkovic et al., 1982). Nonetheless, significant maturation of HPA axis components must occur before response levels approach those of adults, after the third postnatal week (Guillet et al., 1980).
KeywordsCongenital Hypothyroidism Thyroid Status Axis Response Zona Fasciculata Cell Hypothyroid Mouse
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