Role of Neurotransmitters and Electrophysiological Changes in the Hypothalamus Related to Central Adrenocortical Regulation

  • Shaul Feldman
  • David Saphier
Part of the Biochemical Endocrinology book series (BIOEND)


Because afferent neural inputs to the hypothalamus modify considerably the secretion of the adrenal cortex, this laboratory has been involved in the elucidation of the neural pathways which mediate the adrenocortical responses following the stimulation of a variety of afferent stimuli. More recently we have tried to determine the possible role of neurotransmitters involved in the mediation of these responses. In view of the fact that neural stimuli, which produce ACTH secretion, cause also changes in the electrical activity of hypothalamic neurons, we have recently studied in paraventricular nucleus (PVN), which plays a central role in this mechanism, possible electrophysiological correlates of neuroendocrine phenomena in acute and chronic preparations. The purpose of this article is to review briefly previous studies and to describe more recent experiments in the above mentioned areas.


Median Eminence ACTH Secretion Medial Forebrain Bundle Lateral Septum Photic Stimulation 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Shaul Feldman
    • 1
  • David Saphier
    • 1
  1. 1.Department of NeurologyHadassah University Hospital and Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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