Role of Neurotransmitters and Electrophysiological Changes in the Hypothalamus Related to Central Adrenocortical Regulation

  • Shaul Feldman
  • David Saphier
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Because afferent neural inputs to the hypothalamus modify considerably the secretion of the adrenal cortex, this laboratory has been involved in the elucidation of the neural pathways which mediate the adrenocortical responses following the stimulation of a variety of afferent stimuli. More recently we have tried to determine the possible role of neurotransmitters involved in the mediation of these responses. In view of the fact that neural stimuli, which produce ACTH secretion, cause also changes in the electrical activity of hypothalamic neurons, we have recently studied in paraventricular nucleus (PVN), which plays a central role in this mechanism, possible electrophysiological correlates of neuroendocrine phenomena in acute and chronic preparations. The purpose of this article is to review briefly previous studies and to describe more recent experiments in the above mentioned areas.

Keywords

Dopamine Cortisol Serotonin Dexamethasone Glucocorticoid 

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References

  1. Antoni, F.A., Palkovits, M., Makara, G.B., 1983, Immunoreactive corticotropin releasing hormone in the hypothalamoinfundibular tract. Neuroendocrinelogy 36:415.CrossRefGoogle Scholar
  2. Brownstein, M.J., Palkovits, M., Tappaz, M.L., Saavedra, J.M., and Kizer, S., 1976, Effect of surgical isolation of the hypothalamus on its neurotransmitter content. Brain Res. 117:287.PubMedCrossRefGoogle Scholar
  3. Bruhn, T.O., Plotsky, M., and Vale, W.W., 1984, Effect of paraventricular lesions on corticotropin-releasing factor (CRF)-like immunoreactivity in the stalk-median eminence: studies on the adrenocorticotropin response to ether stress and exogenous CRF, Endocrinology 114:57.PubMedCrossRefGoogle Scholar
  4. Conrad, L.C.A., and Pfaff, D.W., 1975, Axonal projections of medial preoptic and anterior hypothalamic neurones, Science, NY 190:1112.Google Scholar
  5. Cuello, A.C., Shoemaker, W.J., and Ganong, W.F., 1974, Effect of 6-hydroxydopamine on hypothalamic norepinephrine and dopamine content, ultrastructure of the median eminence and plasma corticosterone, Brain Res.78:57.PubMedCrossRefGoogle Scholar
  6. Dunn, J.D., and Orr, S.E., 1984, Differential plasma corticosterone responses to hippocampal stimulation. Exp. Brain Res., 54:1.PubMedCrossRefGoogle Scholar
  7. Dyer, R.G., and Saphier, D.J., 1981, Electrical activity of anti-dromically identified tuberoinfundibular neurones during stimulated release of luteinizing hormone and prolactin in prooestrous rats. J. Endocr. 89: 35.PubMedCrossRefGoogle Scholar
  8. Feldman, S., 1981, Introduction to The extrahypothalamic structures in neuroendocrine regulation, in: 28th International Congress of Physiological Sciences, E. Stark, G.B. Makara, Ac.Zs. Endroczi, eds., Pergamon Press.Google Scholar
  9. Feldman, S. 1983, Neurophysiological changes in the limbic system related to adrenocortical secretion, in: Integrative Neurohumoral Mechanisms, E. Endroczi, D. de Wied, L. Angelucci, and U. Scapagnini, eds., Elsevier Science Publishers.Google Scholar
  10. Feldman, S., and Conforti, N., 1976, Inhibition and facilitation of feedback influences of dexamethasone on adrenocortical responses to ether stress in rats with hypothalamic deafferentations and brain lesions, Acta Endocr. Copenh. 82:785.Google Scholar
  11. Feldman, S., and Conforti, N., 1980, Participation of the dorsal hippocampus in the glucocorticoid feedback effect on adrenocortical activity, Neuroendocrinology, 30:52.PubMedCrossRefGoogle Scholar
  12. Feldman, S., and Conforti, N., 1980a, The role of the medial septal nucleus in mediating adrenocortical responses to somatosensory stimulation, J Neur. Res. 5:19.CrossRefGoogle Scholar
  13. Feldman, S., and Conforti, N., 1980b, Inhibition of adrenocortical responses following olfactory stimulation in rats with stria terminalis lesions, Neuroscience, 5:1323.PubMedCrossRefGoogle Scholar
  14. Feldman, S., and Conforti, N., 1984, Mediation of adrenocortical responses by medial forebrain bundle following frontal cortex stimulation, Isr J Med Sci., 20:449.PubMedGoogle Scholar
  15. Feldman, S., Conforti, N., Chowers, I., and Siegel, R.A., 1981, Effects of sciatic nerve stimulation of ACTH secretion in intact and in variously hypothalamic deafferentated male rats. Exp. Brain Res. 42:486.PubMedCrossRefGoogle Scholar
  16. Feldman, S., Conforti, N., Siegel R.A., 1982, Adrenocortical responses following limbic stimulation in rats with hypothalamic deafferentations. Neuroendocrinlogy, 35: 205.CrossRefGoogle Scholar
  17. Feldman, S., Melamed, E., Conforti, N., and Weidenfeld, J., 1984, Effect of central serotonin depletion on adrenocortical responses to neural stimuli, Exp.Neurol.85: in press.Google Scholar
  18. Feldman, S., Melamed, E., Conforti, N., and Weidenfeld, J., 1984b, Inhibition in corticotrophin and corticosterone secretion following photic stimulation in rats with 6-hydroxydopamine injection into the medial forebrain bundle, J Neurosci. Res. 12:87.PubMedCrossRefGoogle Scholar
  19. Feldman, S., Siegel, R.A., and Conforti, N., 1983, Differential effects of medial forebrain bundle lesions on adrenocortical responses following limbic stimulation, Neuroscience 9:1.CrossRefGoogle Scholar
  20. Feldman, S., Siegel, R.A., Weidenfeld, J., Conforti, N., and Melamed, E., 1983, Role of medial forebrain bundle catecholaminergic fibers in the modulation of glucocorticoid negative feedback effects. Brain Res. 260:29 7.Google Scholar
  21. Feldman, S., Siegel, R.A., Weidenfeld, J., Conforti, N., and Melamed, E., 1984a, Adrenocortical responses to ether stress and neural stimuli in rats following the injection of 6-hydroxydopamine into the medial forebrain bundle. Exp. Neurol. 83:215.PubMedCrossRefGoogle Scholar
  22. Fuxe, K., Hokfelt, T., Johnsson, G., Levine, S., Lidfriak, P., and Lofstrom, A., 1973, Brain and pituitary-adrenal interactions, studies on central monoamine neurons. in: Brain-Pituitary-Adrenal Interrelationships. Brodish A., and Redgate, E.S., eds., Karger, Basel.Google Scholar
  23. Gillies, G., and Lowry, P.J., 1982, Corticotropin-releasing hormone and its vasopressin component, in: Frontiers in Neuroendocrinology, Ganong, W.F. and Martini, L. eds., Raven Press, New York.Google Scholar
  24. Holmes, M.C., Wynn, P.C., Hauger, R.L., Millan, M.A., Catt, K.J., and Aguilera, G., 1984, Characterization and localization of corticotropin-releasing factor receptors in the rat brain. Abst#959. 7th Intl. Congr. Endocrinology, Quebec, Canada.Google Scholar
  25. Holzwarth, M., Wilkinson, C.W., Dallman, M.F., 1980, Compensatory adrenal growth in immature and mature male rats. Neuroendocrinelogy 31:34.CrossRefGoogle Scholar
  26. Jones, M.T., Hillhouse, E., and Burden, J., 1976, secretion of corticotropin-releasing hormone in vitro, in: Frontiers in Neuroendocrinology, Martini, L., and Ganong W.F. eds., Raven Press, New York.Google Scholar
  27. Joseph, S.A., and Knigge, K.M., 1983, Corticotropin releasing factor: Immunocytochemical localization in rat brain. Neurosci. Lett. 35:135.PubMedCrossRefGoogle Scholar
  28. Karteszi, M., Palkovits, M., Kiss, J.Z., Kanyicska, B., Fekete, M.I. K., and Stark, E., 1981, Lack of correlation between hypothalamic serotonin and the ether-induced ACTH secretion in adrenalectomized rats. Neuroendocrinology, 32:7.PubMedCrossRefGoogle Scholar
  29. Koikegami, H., Hirata, Y., and Oguma, J., 1967, Studies on the paralimbic brain structures. Fol.Psych, et Neurol. Jap., 21:151.Google Scholar
  30. Krieger, D.T., 1973, Neurotransmitter regulation of ACTH release, Mt. Sinai J Med. 3: 302.Google Scholar
  31. Leng, G., 1981, The effects of neural stalk stimulation upon firing patterns in rat supraoptic neurones. Exp. Brain Res., 41:135.PubMedCrossRefGoogle Scholar
  32. Makara, G.B., Stark, E., and Palkovits, M., 1980, Reevaluation of the pituitary-adrenal response to ether in rats with various cuts around the medial basal hypothalamus, Neuroendocrinology, 30:38.PubMedCrossRefGoogle Scholar
  33. Moore, R.Y., and Kromer, L.F., 1978, The organization of central catecholamine neuron system, in: Neuropharmacology and Behavior, B. Haber and M.H. Aprison, Eds., Plenum Publishing Corp.Google Scholar
  34. Nieuwenhuys, R.L., Geeraedts, M.G., and Veening, J.G., 1982, The medial forebrain bundle of the rat. I. General Introduction, J. Comp. Neurol. 206:49.PubMedCrossRefGoogle Scholar
  35. Palkovits, M., Saavedra, J.M., Jacobowitz, D.M., Kizer, J.S., Zaborszky, L., and Brownstein, M.J., 1977, Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophane hydroxylase levels, Brain Res. 130:121.PubMedCrossRefGoogle Scholar
  36. Plotsky, O.M., and Vale, W., 1984, Hemorrhage-induced secretion of corticotropin-releasing factor-like immunoreactivity into the rat hypophysial portal circulation and its inhibition by glucocorticoids. Endocrinology 114:164.PubMedCrossRefGoogle Scholar
  37. Redgate, E.S., and Fahringer, E.E., 1973, A comparison of the pituitary adrenal activity elicited by electrical stimulation of preoptic, amygdaloid and hypothalamic sites in the rat brain Neuroendocrinology, 12:334.PubMedCrossRefGoogle Scholar
  38. Saphier, D.J., and Dyer, R.G., 1980, Bursting activity in tuberoin-fundibular neurones during electrical stimulation of the rostral hypothalamus. Exp. Brain Res. 39:113.PubMedCrossRefGoogle Scholar
  39. Saphier, D.J., and Dyer, R.G., 1981, Effects of neonatal exposure to monosodium glutamate on the electrical activity of neurones in the mediobasal hypothalamus, and on the plasma concentrations of thyroid-stimulating hormone and prolactin, following stimulation of the rostral hypothalamus in adult female rats. J. Endocr. 89:379.PubMedCrossRefGoogle Scholar
  40. Sawchenko, P.E., and Swanson, L.W., 1983, The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J. Comp. Neurol. 218:121.PubMedCrossRefGoogle Scholar
  41. Siegel, R. A., Chowers, I., Conforti, N., and Feldman, S., 1980, Corticotropin and corticosterone secretory patterns following acute neurogenic stress, in intact and in variously hypothalamic deafferented male rats, Brain Res. 188: 399.PubMedCrossRefGoogle Scholar
  42. Siegel, R.A., Chowers, I., Conforti, N., and Feldman, S., 1981, The role of the medial forebrain bundle in the mediation of the hypothalamic-hypophyseal-adrenal reponses to acute neurogenic stress, Brain Res. Bull. 6:113.PubMedCrossRefGoogle Scholar
  43. Silverman, A.J., and Oldfield, B.J., 1984, Synaptic input to vasopressin neurons of the paraventricular nucleus (PVN). Peptides 5 (Suppl.) 1:139.CrossRefGoogle Scholar
  44. Swanson, L.W., Sawchenko, P.E., Rivier, J., and Vale W.W., 1983, Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study, Neuroendocrinology 36:165.PubMedCrossRefGoogle Scholar
  45. Weiner, R.I., Ganong, W.F., 1978, Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol. Rev. 58:905.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Shaul Feldman
    • 1
  • David Saphier
    • 1
  1. 1.Department of NeurologyHadassah University Hospital and Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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