Calcium-Activated Phospholipid-Dependent Protein Kinase: A Novel Signal Transduction Mechanism in the Pituitary
The hypothalamic peptide hormones exert their stimulatory effect upon the pituitary by elevation of intracellular cyclic AMP (cAMP) and/or calcium levels (for review see Naor, 1982; Gershengorn, 1982). cAMP was implicated as the second messenger for corticotropin-releasing factor (CRF) and growth hormone releasing hormone (GHRH) (Giguere et al., 1982; Brazeau et al., 1982). On the other hand, recent studies have suggested that increased phosphoinositide turnover and elevated Ca2+ levels are involved in the mechanism of action of gonadotropin releasing hormone (GnRH), thyrotropin releasing hormone (TRH) and GHRH (Naor, 1982; Snyder and Bleasdale, 1982; Gershengorn, 1982; Sutton and Martin, 1982; Rebecchi et al., 1983; Canonico et al., 1983; Kiesel and Catt, 1984; Raymond et al., 1984; Naor et al., 1984).
KeywordsProtein Kinase Phorbol Ester Pituitary Cell Dependent Protein Kinase Growth Hormone Release Hormone
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