Reaction of Neuroendocrine Cells to Stress

  • Vladimir R. Pantić
Part of the Biochemical Endocrinology book series (BIOEND)


The inhibitory effect of blood corticosteroid levels on ACTH release, caused by stress and the negative feedback exerted by corticosteroids on the hypothalamus, as pointed by Smelik, 1963, is the subject of recent advanced researches and serious discussions. Makara et al., 1970, examined ACTH release induced by traumatic stress in rats with unilateral spinal cord lesion. At that time Stark et al., 1970, paid attention to the afferent pathways of stressful stimuli. The major effect of Cortisol on hypothalamic neurons, when applied directly to the cell membrane by microelectrophoresis, is inhibition of spontaneous activity (Kelly et al., 1982).


Pituitary Cell Peptide Hormone Neuroendocrine Cell Opioid Peptide ACTH Cell 
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© Plenum Press, New York 1985

Authors and Affiliations

  • Vladimir R. Pantić
    • 1
  1. 1.Serbian Academy of Sciences and ArtsBelgradeYugoslavia

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