Skip to main content
SpringerLink
Log in

Reaction of Neuroendocrine Cells to Stress

  • Chapter
Neuroendocrine Correlates of Stress

Part of the book series: Biochemical Endocrinology ((BIOEND))

  • 29 Accesses

Abstract

The inhibitory effect of blood corticosteroid levels on ACTH release, caused by stress and the negative feedback exerted by corticosteroids on the hypothalamus, as pointed by Smelik, 1963, is the subject of recent advanced researches and serious discussions. Makara et al., 1970, examined ACTH release induced by traumatic stress in rats with unilateral spinal cord lesion. At that time Stark et al., 1970, paid attention to the afferent pathways of stressful stimuli. The major effect of Cortisol on hypothalamic neurons, when applied directly to the cell membrane by microelectrophoresis, is inhibition of spontaneous activity (Kelly et al., 1982).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baertschi, A.J., Vallet, P., Baumann, J.B. and Girard, J., 1980. Neuronal lobe pituitary domuldates corticotropin releas in the rat, Endocrinology 106: 878.

    Article  PubMed  CAS  Google Scholar 

  • Barden, N. and Dupont, A., 1982. Distribution and changes in peptides in the brain, in: “Hormonally Active Brain Peptide, Structure and Function”, K. W. McKerns and V. Pantić, eds, Plenum Press, New York, p.307.

    Google Scholar 

  • Barry, J., 1979, Immuno-histochemistry of luteinizing hormone-releasing hormone producing neurons of the vertebrates, Inter.Rev.Cytol. 60: 179.

    Article  CAS  Google Scholar 

  • Blank, M.S., Paneri, A.E., and Friesen, H.G., 1979. Opioid peptides modulate luteinizing hormone secretion during sexual maturation, Science 203: 1129.

    Article  PubMed  CAS  Google Scholar 

  • Bruni, J.F., Van Vught, D., Marschall, S. and Meites, J., 1977. Effect of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone, Life Sci. 21: 461.

    Article  PubMed  CAS  Google Scholar 

  • Cicero, T.J., Meyer, E.R., Gabriel, S.M., Bell, R.D. and Wilcox, C.E., 1980. Morphine exerts testosterone-like effects in the hypothalamus of the castrated male rats, Brain Res. 202: 151.

    PubMed  CAS  Google Scholar 

  • Dallman, M.F. and Yates, F.E., 1969, Dynamic asymmetries in the corticosteroid feedback path and distribution — metebolism — binding elements of the adrenocortical system, Ann.N.Y.Acad.Sci. 156: 696.

    Article  PubMed  CAS  Google Scholar 

  • de Bold, A.J., de Bold, M.L. and Kraicer, J., 1980, Structural relationship between parenchymal and stromal elements in the pars intermedia of the rat adenohypophysis as demonstrated by extracellular space markers. Cell Tissue Res., 207 (3): 347.

    Article  PubMed  Google Scholar 

  • Dufy, B., Dufy-Barbe, L., Arnauld, E. and Vincent, L.D., 1982, Steroids and Membrane-Associated Events in Neurons and Pituitary Cells, in:”Hormonally Active Brain Peptide Structure and Function”, K.W. McKerns, and V. Pantić, eds, Plenum Press, New York, p. 235.

    Google Scholar 

  • Edwards, P.M. and Rousseau, G.G., 1982, Steroid Antagonism of Melanosome Movements Induced by Neuropeptides, in:”Hormonally Active Brain Peptide Structure and Function”, K.W. McKerns and V. Pantić, eds. Plenum Press, New York, p. 349.

    Google Scholar 

  • Feldman, S., Conforti, N. and Chowers, I., 1972, Neural pathways mediating adrenocortical responses to photic and acoustic stimuli, Neuroendocrinology 10: 316.

    Article  PubMed  CAS  Google Scholar 

  • Gautvik, K.M., Hang, E., Sand, O., Iversen, J., Johansen, P.W., Sletholt, K. and Gordeladze, J., 1984, Regulation of prolactin secretion by thyroliberin (TRH) in cultured rat pituitary tumor cells, in:”Regulation of Target Cell Responsiveness”, K.W. McKerns, A. Aakvaag and V. Hansson, eds, Plenum Press, New York, p. 23.

    Google Scholar 

  • Hall, P.F., 1984, The role of the cytoskeleton in the responses of target cells to hormones, in:”Regulation of Target Cell Responsiveness” K.W. McKerns and A. Aakvaag and V. Hansson, eds, Plenum Press, New York p. 205.

    Chapter  Google Scholar 

  • Harder, D.R. and Waters, A., 1984, Electrical activation of arterial muscle, Inter.Rev.Cytol. 89: 138.

    Google Scholar 

  • Hang, E., Gautvik, K.M., Sand, O., Iversen, J.G. and Kriz, M., 1982. Interaction between thyrotropin-releasing hormone and prolactin-producing cells, in:”Hormonaly Active Brain Peptide, Structure and Function”, K.W. McKerns and V. Pantić, eds, Plenum Press, New York, p.537.

    Google Scholar 

  • Hazmun, A., 1984. Nature of the GnRH receptors in the ovary, in: ”Regulation of Target Cell Responsiveness” K.W. McKerns, A. Aakvaag and V. Hansson, eds, Plenum Press, New York, p.23.

    Google Scholar 

  • Hristić, M. and Pantić, V., 1974, Hypothalamus nuclei of rats after head irradiation and adrenocortical hormone treatment, Inter.J.Radiol.Biol. 26 (2): 147.

    Article  Google Scholar 

  • Hristić, M., Pantić, V. and Nickerson, P.A., 1978. Influence of maternal adrenalectomy on pituitary ACTH cells of fetal and neonatal rats, Acta Veterinaria (Belgrade) 18 (6): 231.

    Google Scholar 

  • Jëgou, B., Le Gac, F., Hang, E., Torjesen, P.A. and Hansson, V., 1984. GnRH receptors and GnRH-like activity in the rat testis, in:”Regulation of Target Cell Responsiveness” K.W. McKerns, A. Aakvaag and V. Hansson, eds, Plenum Press, New York, p. 47.

    Chapter  Google Scholar 

  • Jutisz, M., Counis, R. and Corbani, M., 1984, Biosynthesis of pituitary gonadotropins and its regulation by gonadoliberin (GnRH) and estradiol, in: “Regulation of Target Cell Responsiveness” K.W. McKerns, A. Aakvaag and V. Hansson, eds, Plenum Press, New York, p. 385.

    Chapter  Google Scholar 

  • Kalra, P.S., Kalra, S.P., Krulich, L., Fawcett, C.P. and McCann, S.M., 1972. Involvement of norepinephrine in transmission of the stimulatory influence of progesterone on gonadotropin release, Endocrinology 90:1168.

    Article  PubMed  CAS  Google Scholar 

  • Kalra, S.P., 1976, Tissue levels of luteinizing hormone releasing hormone in the preoptic area and hypothalamus and serum concentration of gonadotropins following anterior hypothalamic deafferentiation and estrogen treatment of female rat. Endocrinology 99: 101.

    Article  PubMed  CAS  Google Scholar 

  • Karla, P.S. and Kalra, S.P., 1982, Discriminative effects of testosterone on hypothalamic luteinizing hormone releasing hormone levels and LH secretion in castrated male rats: analysis of dose and duration characteristics, Endocrinology 111: 24.

    Article  Google Scholar 

  • Kalra, S.P., 1982, Mode of Opioid and Catecholamine Involvement in Regulating LH Secretion, in: “Hormonally Active Brain Peptides, Structure and Function”, K.W. McKerns and V. Pantić, eds, Plenum Press, New York, p. 141.

    Google Scholar 

  • Kalra, S.P. and Kalra, P.S., 1984, Hypothalamic microenvironment controlling LH RH secretion, in: “Regulation of Target Cell Responsiveness” K.W. McKerns, A. A. Aakvaag and V. Hansson,eds, Plenum Press, New York, p.127.

    Chapter  Google Scholar 

  • Kanazir, D.T., Ribarac-Stepić, N., Trajković, D., Blečić, G., Radojčić, M., Metlaš, R., Stefanović, D., Katan, M., Perišić, O., Popić, S., and Marković-Djordjević, R., 1979, Structure and regulatory functions of Cortisol receptor. 1. Extragenomic effect dependent on the Cortisol receptor activation, J.Steroid Biochem. 11: 389.

    Article  PubMed  CAS  Google Scholar 

  • Kanazir, D.T., 1982, The role of steroid receptors in the regulation and integration of steroid and peptide hormone actions in common target cells: Facts and speculations, in: “Hormonally Active Brain Peptides, Structure and Function”, K.W. McKerns and V. Pantić, eds, Plenum Press, New York, p. 181.

    Google Scholar 

  • Kelly, M.J., 1982, Electrical effects of steroids in neurons, in: “Hormonally Active Brain Peptides, Structure and Function”, K.W. McKerns and V. Pantić, eds, Plenum Press, New York, p. 253.

    Google Scholar 

  • Khar, A., Debeljuk, L. and Jutisz, M., 1978, Biosynthesis of gonadotropins by rat pituitary cells in culture and pituitary homogenates: Effect of gonadotropin-releasing hormone, Mol.Cell Endocrinology 12: 53.

    Google Scholar 

  • Kilibarda, M. and Pantić, V., 1979, The adrenal cortex of male rats treated with female gonadal steroids, Stereol.Yugosl.2: 65.

    CAS  Google Scholar 

  • Koch, B., Lutz-Bucher, B., Briand, B. and Mialhe, C., 1979, Relationship between ACTH secretion and corticoid binding to specific receptors in perifused adenohypophysis, Neuroendocrinology 28: 169.

    Article  PubMed  CAS  Google Scholar 

  • Koch, B., Lutz-Bucher, B. and Mialhe, C., 1980, Interaction of glucocorticoids, CRF and vasopressin in the regulation of ACTH secretion, in: “Synthesis and Release of Adenohypophyseal Hormones”, M. Jutisz and K.W. McKerns, eds, Plenum Press, New York, p. 561.

    Google Scholar 

  • Krulisch, L., 1979, Central neurotransmitters and the secretion of prolactin, GH, LH and TSH, Ann.Rev.Physiol. 41: 603.

    Google Scholar 

  • Li, H.C., 1972, Hormones of the adenohypophysis, Proc.Am.Philos.Soc.116: 365.

    CAS  Google Scholar 

  • Loh, H.H., Tseng, L.F., Wie, E. and Li, C.H., 1976, Endorphin is a potent analgesic agent, Proc.Natl.Acad.Sci.USA 73: 2895.

    Article  PubMed  CAS  Google Scholar 

  • Lord, J.A.H., Waterfield, A., Hughes, J. and Kosterlitz, H.W., 1977, Endogenous opioid peptides: Multiple agonists and receptors, Nature (London) 267: 495.

    Google Scholar 

  • Lowry, P.J. and Scott, A.P., 1975, The evolution of vertebrate corticotrophin and melanocyte stimulating hormone, Gen.Comp.Endocrinol. 26: 16.

    Article  PubMed  CAS  Google Scholar 

  • Lutz-Bucher,B., Koch,B. and Mailhe,C., 1977, Comparative in vitro activity of vasopressin and hypothalamic median eminence extract, Neuroendocrinology 23: 181.

    Article  PubMed  CAS  Google Scholar 

  • Makara,G.B., Stark,E. and Mihaly,K., 1970, Corticotrophin release induced by traumatic stress in rats with unilateral spinal cord lesion, Acta Physiol.Acad.Sci.Hung. 38; 199.

    PubMed  CAS  Google Scholar 

  • Martial,J.A., Baxter,D.J., Goodman,M.H. and Seeburg,H.P., 1977, Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones, Proc.Natl.Acad.Sci.USA 74: 1816.

    Google Scholar 

  • Martial,J.A., Truong,A.T., Laverriere,J.N. and Morin,A., 1982, Structure and regulation of the prolactin gene, Program of the Europlan INSERM Symposium on “Multi-hormonal Regulation in Neuroendocrine Cells”, Colmar (France) September 1–4, 53 (Abstr.32).

    Google Scholar 

  • McEwen,B.S. and Luine,V.N., 1978, Specificity, mechanisms and functional significance of steroid-receptor interaction in the brain and pituitary, in: “Biologie Cellulaire des Processus Neurosécrétores Hypothalamique, J.D.Vincent and C.Kordon, eds, CNRS, Paris, p. 239.

    Google Scholar 

  • Milković,K., Paunović,J., Kniewald,Z., Milković,S., 1973, Maintenance of the plasma corticosterone concentration of adrenalectomized rat by the fetal adrenal gland, Endocrinology 93: 115.

    Article  PubMed  Google Scholar 

  • Naor,Z., Clayton,R.N. and Catt,K.J., 1980, Characterization of gonadotropin releasing hormone receptors in cultured pituitary cells, Endocrinology 107: 1144.

    Google Scholar 

  • Nickerson,P.A., Hristic,M. and Pantić,V., 1978, Influence of maternal adrenalectomy on the ultrastructure of the adrenal gland in neonatal rats, Cell Tissue Res. 189: 277.

    Article  PubMed  CAS  Google Scholar 

  • Nolin,J., 1981, Profiles of target cells prolactin and adrenocorticotropin during lactation diestrus, in: “Reproductive Processes and Contraception”, K.W. McKerns, ed, Plenum Press, New York, p.195.

    Chapter  Google Scholar 

  • Ojeda,S.R., Negro-Vilar,A. and McCann,S.M., 1982, Evidence for involvement of alpha-adrenerg-c receptors in norepinephrine — induced prostaglandin E2 and luteinizing hormone-releasing hormone release and the median eminence, Endocrinology 110: 409.

    Article  PubMed  CAS  Google Scholar 

  • Palkovits,M., 1982, Recent data on neuropeptide mapping in the central nervous system, in: “Hormonally Active Brain Peptides, Structure and Function”, K.W. McKerns and V.Pantić, eds, Plenum Press, New York, p.279.

    Google Scholar 

  • Pantić,V., 1974. Gonadal steroids and hypothalamo-pituitary-gonadal axis, Inter.Symp. on Sexual Endocrinol. of Perinatal Period, INSERM, Paris, 32: 97.

    Google Scholar 

  • Pantić, V., 1975. The specificity of pituitary cells and regulation of their activities, Int.Rev.Cytology 40: 153.

    Article  Google Scholar 

  • Pantić,V.R. and Simic,M., 1977, Sensitivity of pituitary pars intermedia to castration or gonadal steroids, Bull.Acad.Serbe Sci.Arts, T, LX (16): 67.

    Google Scholar 

  • Pantić,V.R. and Kilibarda,M., 1978, Adrenal cortex of rats treated with oestradiol neonatally and during sexual maturity, Acta Veterinaria 28: 1.

    Google Scholar 

  • Pantić,V.R., 1980, Adenohypophyseal cell specificities and gonadal steroids, in: “Synthesis and Release of Adenohypophyseač Hormones”, M.Jutisz and K.W.McKerns, eds, Plenum Press, New York, p.335.

    Google Scholar 

  • Pantić,V.R., 1981. Sensitivity of pituitary gonadotropic cells and gonads to hormones, in:”Reproductive Processes and Contraception”, K.W.McKerns, ed. Plenum Press, New York, p. 47.

    Chapter  Google Scholar 

  • Pantić,V.R., 1982. Genesis and properties of pituitary ACTH, MSH, prolactin and GH producing cells, in: “Hormonally Active Brain Peptides, Structure and Function”, K.W.McKerns and V.Pantić, eds. Plenum Press, New York, p. 504.

    Google Scholar 

  • Pantić,V., 1984, Prolactin target cells in rats treated with gonadal steroids, in, ”Regulation of Target Cell Responsiveness” K.W.McKerns, A.Aakvaag and V.Hansson, eds. Plenum Press, New York, p. 283.

    Chapter  Google Scholar 

  • Pavić,D., Živković,N., Pantić,V. ana Martinović,P., 1977. Glukoprotein synthesizing cells in the anterior pituitaries transplanted into hypophysectomized male rats, Arhiv bioloških nauka, 27, 1–2: 1.

    Google Scholar 

  • Peck,E.J. and Keiner,K.L., 1984, Differential sensitivity of estrogen targets: Receptors and responses, in: “Regulation of Target Cell Responsiveness”, K.W.McKerns, A.Aakvaag and V.Hansson, eds, Plenum Press, New York, pg. 256.

    Google Scholar 

  • Pietras,R.J. and Szego,C.M., 1979, Estrogen receptors in uterine plasma membrane, J.Steroid Biochem. 11:1471.

    Article  PubMed  CAS  Google Scholar 

  • Poeggel,G., Luppa,H., Bernstein,H.E.G. and Weiss,J., 1984. Histochemistry of adenylate cyclase, Inter.Rev.Cytol. 89: 35.

    Article  CAS  Google Scholar 

  • Rotsztejn,W., Drouva,S., Pattou,E. and Kordon,C., 1978. Metenkephalin inhibits in vitro dopamine-induced LHRH release from medio-basal hypothalamus of male rats, Nature (London) 274:281.

    Article  CAS  Google Scholar 

  • Roubos,E.W., 1984. Cytobiology of the ovulation-neurohormone producing neuroendocrine caudo-dorsal cells of Lymnaea stagnalis, Inter.Rev.Cytol., vol.89:295.

    Article  CAS  Google Scholar 

  • Saint Gerons,H., 1961. Particularites anatomiques et histologiques de l’hypophyse chez les Squamata, Arch.Biol. 72:211.

    Google Scholar 

  • Seppälä,M., Wahlström,T. and Leppäluoto,J., 1979. Luteinizing hormone releasing factor (LFR)-like immuno-reactivity in rat pancreatic islet cells, Life Sci. 25: 1489.

    Google Scholar 

  • Shaar,C.J. and Clemens,J.A., 1980, The effect of opiate agonists on growth hormone and prolactin release in rats, Fed.Proc. 38: 2539.

    Google Scholar 

  • Sharpe,R.M. and Fraser,H.M., 1980. Leydig cell receptors for luteinizing hormone releasing hormone and its agonists and their modulation by administration or deprivation of the releasing hormone, Biochem.Biophys.Res.Commun., 95: 256.

    Article  PubMed  CAS  Google Scholar 

  • Sharpe,R.M., 1980, Extra-pituitary actions of LHRH and its agonists, Nature (London) 286: 12.

    Article  PubMed  CAS  Google Scholar 

  • Sharpe,R.M., 1982. Cellular aspects of the inhibitory actions of LH-RH on the ovary and testes, J.Reprod. Fertility, 64: 517.

    Google Scholar 

  • Smelik,P.G., 1963. Relation between blood level of corticoids and their inhibiting effect on the hypophyseal stress response, Proc.Soc.Exp.Biol.Med. 113: 616.

    PubMed  CAS  Google Scholar 

  • Snyder,S.H., 1980. Brain peptides as neurotransmitters, Science 209: 976.

    Article  PubMed  CAS  Google Scholar 

  • Sowers,J.R., Carlson,H.E., Brautbar,N. and Hershman,J.M., 1977. Effect of dexamethason on prolactin and TSH responses to TRH and metoclopamide in man, J.Clin.Endocrinol.Metab. 44: 237.

    Article  PubMed  CAS  Google Scholar 

  • Stark,E., Makara,G.B., Palkovits,M. and Mihály,K., 1970. Afferent pathways of stressful stimuli: Their dependence on strength and the time elapsed after the onset of stimulation, Acta Physiol.Acad.Sci.Hung. 38:43.

    Google Scholar 

  • Stark,E., Kárteszi,M., Rappay,G. and Makara,G.B., 1981, Effects of treatment with adrenocorticotrophin on the hypothalamo-pituitary-adrenal system, J.Endocrinol. 88: 131.

    Article  PubMed  CAS  Google Scholar 

  • Stark,E., Makara,G.B., Marton,J. and Palković,M., 1973/74. ACTH release in rats after removal of the medial hypothalamus, Neuroendocrinology 13: 224.

    Article  PubMed  CAS  Google Scholar 

  • Stark,K., Taube,H.D. and Borowski,E., 1977. Presynaptic receptor system in catecholaminergic transmission, Biochem.Phyrmacol. 26: 259.

    Article  Google Scholar 

  • Stark,E., and Makara,G.B., 1982. Stress, corticoliberin (CRF) and glucocorticoids in the regulation of ACTH release, in:”Hormonally Active Brain Peptide, Structure and Function”, K.W. McKerns and V. Pantić, eds. Plenum Press, New York, p. 157.

    Google Scholar 

  • Stošić,N., Pantić,V., Pavlović-Hournac,M. and Radivojević,D., 1965. Investigation of hypothalamus and hypophysis of thyroidectomized rats after the transplantation of irradiated grafts thyroid gland, Iugoslav. Physiol.Pharmacol.Acta 1 (2): 194.

    Google Scholar 

  • Jing,S.Y. et Guillemin,R., 1979, Gonadostatine et gonadocrinine, polypeptides d’origine ovarienne á activities hypophysiotropes, C.R. Hebd.Acad.Ser. D. (Paris) 289: 943.

    Google Scholar 

  • Yu,L.Y., Tushinski,J.R. and Bancroft,F.C., 1977. Glucocorticoid induction of growth hormones synthesis in a strain of rat pituitary cells, J.Biol.Chem.252: 3870.

    PubMed  CAS  Google Scholar 

  • Wamsley,J., Young,W.S. and Kuhar,M.J., 1980. Immunohistochemical localization of enkephalin in rat forebrain, Brain Res. 190: 153.

    Article  PubMed  CAS  Google Scholar 

  • Watson,S., Richards,G.W., Ciarvanello,R.D. and Barchas,J.D., 1980. Interaction of opiate peptides and noradrenalin system: Light microscopic studies, Peptides 1: 30.

    Google Scholar 

  • Wolfe,B.B., Harden,K.T. and Molinoff,B.R., 1976. Adrenergic receptors in rat liver: Effect of Adrenalectomy, Proc.Natl.Acad.Sci.USA 73: 1343.

    Google Scholar 

  • Žgurić,M. and Pantić,V., 1970. Hypothalamus and Hypophysis in rats following adrenalectomy and head irradiation with X-rays, Iugoslav.Physiol.Pharmacol. Acta 6, 3: 471.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Serbian Academy of Sciences and Arts, Belgrade, Yugoslavia

    Vladimir R. Pantić

Authors
  1. Vladimir R. Pantić
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

  2. Institute for Biological Research, Belgrade, Yugoslavia

    Vladimir Pantić

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Pantić, V.R. (1985). Reaction of Neuroendocrine Cells to Stress. In: McKerns, K.W., Pantić, V. (eds) Neuroendocrine Correlates of Stress. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8553-0_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8553-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8555-4

  • Online ISBN: 978-1-4684-8553-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation