The Significance of the Cholinergic-Adrenergic Interactions in the Response of the Rat to Immobilization Stress
A conceptual model of dual stress pathways has been postulated by Henry and Stephens (1977). Some stressors, particularly the psychosocial ones activate the pituitary-adrenocortical system, or the sympatho-adre-nomedullary system. The first system is activated particularly when there is a loss of control by the organism, a state known to lead to depression. This type of stress is characterized by an increased secretion of corticosterone and corticotropine, whereas the secretion of catecho-lamines is unaltered. On the other hand, the sympatho-adrenomedullary system is particularly activated during the "fight and flight" reaction, in which the organism is chalanged in its control of the environment. In this type of stress the release of catecholamines is significantly in-creased, whereas the plasma corticosterone level remains unchanged. In the central nervous system, amygdala is thought to the primarily in-volved in this type of stress reaction.
KeywordsPlasma Catecholamine Immobilization Stress Hypertensive Response Plasma Catecholamine Level Blood Pressure Rise
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