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Prostaglandins as Transducers of Proliferation Signals in Microvascular Endothelial Cells and the Pharmacological Control of Angiogenesis

  • Anthony C. Allison
  • W. Joseph Kowalski

Abstract

The control of angiogenesis is a problem of interest to cell biologists as well as practical importance. On the one hand, angiogenesis is a component of the pathogenesis of common diseases including cancer, chronic inflammation and the retinopathy of diabetes mellitus. A drug able to inhibit angiogenesis without major side effects could have wide utility. On the other hand angiogenesis is required for healing of avascular ulcers, burns and other wounds, and an agent able to increase angiogenesis might accelerate wound healing.

Keywords

Endothelial Cell Epidermal Growth Factor Receptor Adenylate Cyclase Cyclooxygenase Inhibitor Angiogenic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Anthony C. Allison
    • 1
  • W. Joseph Kowalski
    • 1
  1. 1.Department of ImmunologySyntex ResearchPalo AltoUSA

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