Prostaglandins as Transducers of Proliferation Signals in Microvascular Endothelial Cells and the Pharmacological Control of Angiogenesis
The control of angiogenesis is a problem of interest to cell biologists as well as practical importance. On the one hand, angiogenesis is a component of the pathogenesis of common diseases including cancer, chronic inflammation and the retinopathy of diabetes mellitus. A drug able to inhibit angiogenesis without major side effects could have wide utility. On the other hand angiogenesis is required for healing of avascular ulcers, burns and other wounds, and an agent able to increase angiogenesis might accelerate wound healing.
KeywordsEndothelial Cell Epidermal Growth Factor Receptor Adenylate Cyclase Cyclooxygenase Inhibitor Angiogenic Effect
Unable to display preview. Download preview PDF.
- Allison, A.C., Rooks, W. and Segre, E.J. Naproxen. In Anti-inflammatory and anti-rheumatic drugs: newer ant-inflammatory drugs ed. by K.D. Rainsford, CRC Press. Boca Raton FL. Vol. 2:171–212, 1985.Google Scholar
- Davison, P.M. and Karasek, M.A. Human dermal microvascular endothelial cells in vitro: effect of cyclic AMP on cellular morphology and proliferation rate. J. Cell. Physiol. 106:253–258.Google Scholar
- Pike, L.J., Marquardt, H., Todaro, G., Gallis, B., Casnellie, J.E., Bornstein, P., and Krebs, E.G. Transforming growth factor and epidermal growth factor stimulate phosphorylation of a synthetic tyrosine-containing peptide in a similar manner. J. Biol. Chem. 257:14628–14631, 1982.PubMedGoogle Scholar
- Rooks, W.H. II, Maloney, P.J., Shott, L.D., Schuler, M.E., Sevelius, H., Strosberg, A.M., Tanenbaum, L., Tomolonis, A.J., Wallach, M.B., Waterbury, D. and Jee, J.P. The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt. Drugs Exptl. Clin. Res. 8:479–492, 1985.Google Scholar
- Yoshida, T., Miyagawa, K., Odagiri, H., Sakamoto, H., Little, P.F.R., Terada, M. and Sugimura, T. Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc. Natl. Acad. Sci. U.S.A.. 84:7305–7309, 1987.PubMedCrossRefGoogle Scholar