Endothelial Specific Binding Sites for Permeant Plasma Macromolecules: Albumin Binding Proteins

  • Nicolae Simionescu
  • Maya Simionescu


Plasma molecules interact with vascular endothelium primarily at its luminal cell surface. The plasma-endothelial interface is a complex, dynamic composite of the endothelial cell glycocalyx (ECG) and some transiently associated plasma constituents. The luminal ECG bearing a net negative charge is a mosaic formed by the ectodomaines of membrane protein, glycoprotein, glycolipids and proteoglycans. To these intrinsic components, molecules produced in other tissues are secondarily attached to perform their activities (e.g. lipoprotein lipase, thrombin). Several ECG components are preferentially distributed, generating microdomains of different chemistry and charge and/or charge density. These domains characteristically correspond to structures potentially involved in endocytosis and transcytosis of macromolecules (for reviews see Simionescu N., 1983; Simionescu M. and Simionescu N., 1986). Within the thin unstirred layer of plasma adjacent to ECG, molecules interact with endothelial cell (EC) either non-specifically or specifically.


Capillary Endothelium Coated Vesicle Microvascular Endothelium High Affinity Binding Site Arterial Endothelium 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Nicolae Simionescu
    • 1
  • Maya Simionescu
    • 1
  1. 1.Institute of Cellular Biology and PathologyBucharestRomania

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