Factors Affecting the Fluidity of the Endothelial Cell Plasma Membrane
Pulmonary endothelial cells form a continuous monolayer on the luminal surface of the lung vasculature, and they provide, primarily via their plasma membranes, a thromboresistant, semipermeable barrier that regulates transport of water, solutes, and particulate material between blood and tissues in the lung. The pulmonary endothelium is also a metabolically active tissue, metabolizing a variety of biologically active substances in the circulation either by interiorizing the substance by way of specific plasma membrane transport processes or by way of enzymatic activity at the luminal aspect of the plasma membrane (Ryan and Ryan, 1977). The structural and functional integrity of the pulmonary vascular endothelial cell and its plasma membrane is, therefore, of major importance for normal vascular and organ function.
KeywordsNitrogen Dioxide Lipid Domain Pulmonary Artery Endothelial Cell Plasma Membrane Fluidity Pulmonary Endothelial Cell
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