Endothelium-Derived Vasodilators

  • S. Moncada
  • R. M. J. Palmer
  • E. A. Higgs


The importance of the endothelium in vessel wall homeostasis has recently become apparent. The vascular endothelium has been discovered to generate two potent vasodilators, prostacyclin (Moncada et al., 1976) and endothelium-derived relaxing factor (EDRF; Furchgott and Zawadzki, 1980) in response to a number of chemical or mechanical stimuli. Prostacyclin is the most potent inhibitor of platelet aggregation yet discovered (for review see Moncada, 1982). EDRF is an inhibitor of both platelet aggregation (Radomski et al., 1987a) and adhesion (Radomski et al., 1987b).


Nitric Oxide Nitric Oxide Platelet Aggregation Platelet Adhesion Inhibit Platelet Aggregation 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • S. Moncada
    • 1
  • R. M. J. Palmer
    • 1
  • E. A. Higgs
    • 1
  1. 1.Wellcome Research LaboratoriesLangley Court, Beckenham KentUK

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