Modulation of Endothelial Permeability: Role of Receptors, Second Messengers and Ion Channels
The microvascular endothelium has traditionally been viewed as a passive filter inserted between the circulating blood and the tissue. In 1969, Majno et al., proposed that endothelial cells may actively control vascular permeability. This happens when chemical mediators released from storage cells in the tissue specifically stimulate the endothelium and within seconds completely change the permeability characteristics of the microvascular membrane. The activation of the endothelium involving receptor stimulation, activation of ion channels in the cell membrane and intracellular signalling, is now being studied at the level of single endothelial cells (Hallam & Pearson 1986, Olesen et al., 1988b).
KeywordsAortic Endothelial Cell Bovine Aortic Endothelial Cell Microvascular Endothelium Endothelial Cell Membrane Venular Endothelium
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