Modulation of Endothelial Permeability: Role of Receptors, Second Messengers and Ion Channels

  • Søren-Peter Olesen


The microvascular endothelium has traditionally been viewed as a passive filter inserted between the circulating blood and the tissue. In 1969, Majno et al., proposed that endothelial cells may actively control vascular permeability. This happens when chemical mediators released from storage cells in the tissue specifically stimulate the endothelium and within seconds completely change the permeability characteristics of the microvascular membrane. The activation of the endothelium involving receptor stimulation, activation of ion channels in the cell membrane and intracellular signalling, is now being studied at the level of single endothelial cells (Hallam & Pearson 1986, Olesen et al., 1988b).


Aortic Endothelial Cell Bovine Aortic Endothelial Cell Microvascular Endothelium Endothelial Cell Membrane Venular Endothelium 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Søren-Peter Olesen
    • 1
  1. 1.Department of General Physiology and Biophysics, The Panum InstituteUniversity of CopenhagenCopenhagenDenmark

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