Transduction of Purinoceptor-Mediated Endothelial Cell Responses
An earlier chapter in this volume (Gordon) has described pathophysiological processes that lead to the generation of extracellular or circulating adenine nucleotides and adenosine. It also summarized the interactions of purines with the endothelial cell surface, reviewing the features of the adenosine transporter and ectonucleotidase enzymes that together constitute a system for regulating the concentrations of purines in plasma; and it outlined the types of purinoceptor (P1, recognizing adenosine; and P2, recognizing ATP or ADP) present on endothelium. In this chapter, we shall discuss further the characterization of the purinoceptors, describing what is currently known of purinoceptor-mediated signal transduction systems in endothelium, and suggesting avenues for future exploration of this topic.
KeywordsAdenosine Receptor Phorbol Ester Aortic Endothelial Cell Bovine Aortic Endothelial Cell Free Calcium Concentration
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