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Transduction of Purinoceptor-Mediated Endothelial Cell Responses

  • J. D. Pearson
  • T. D. Carter

Abstract

An earlier chapter in this volume (Gordon) has described pathophysiological processes that lead to the generation of extracellular or circulating adenine nucleotides and adenosine. It also summarized the interactions of purines with the endothelial cell surface, reviewing the features of the adenosine transporter and ectonucleotidase enzymes that together constitute a system for regulating the concentrations of purines in plasma; and it outlined the types of purinoceptor (P1, recognizing adenosine; and P2, recognizing ATP or ADP) present on endothelium. In this chapter, we shall discuss further the characterization of the purinoceptors, describing what is currently known of purinoceptor-mediated signal transduction systems in endothelium, and suggesting avenues for future exploration of this topic.

Keywords

Adenosine Receptor Phorbol Ester Aortic Endothelial Cell Bovine Aortic Endothelial Cell Free Calcium Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. D. Pearson
    • 1
  • T. D. Carter
    • 1
  1. 1.Section of Vascular BiologyMRC Clinical Research CentreHarrowUK

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