Modulation of the Guanylate Cyclase -cGMP System by Vasodilators and the Role of Free Radicals as Second Messengers

  • Ferid Murad

Abstract

This brief article will review some of the studies, from this laboratory and others, that have led to our present understanding of the synthesis of cyclic GMP and its role in smooth muscle relaxation and more specifically its role to mediate the effects of several classes of vasodilators. The regulation of the synthesis of cyclic GMP and some of its effects in several model systems have recently been reviewed in some detail. Readers are referred to these reviews (Waldman and Murad, 1987; Murad, 1986; Leitman and Murad, 1987) and the references therein for a more detailed discussion.

Keywords

Nitrite Histamine Thiol Catalase Porphyrin 

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References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Ferid Murad
    • 1
  1. 1.Departments of Medicine and PharmacologyStanford UniversityStanfordUSA

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