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Receptors for Extracellular Matrix Proteins in Endothelial Cells

  • Elisabetta Dejana
  • G. Conforti
  • A. Zanetti
  • M. G. Lampugnani
  • P. C. Marchisio

Abstract

The basement membrane of endothelial cells (EC) is organized as a complex network of numerous glycoproteins which include fibronectin (FN), vitronectin (VN), collagens and von Willebrand factor (vW). Beside these substrata which are directly produced by EC, fibrinogen (FG) and fibrin tend to accumulate at sites of vascular injury and may provide a new matrix over which EC can migrate and proliferate (Dejana et al., 1988). The interaction of EC with the protein components of the matrix, causes a series of cell responses as adhesion, spreading, cytoskeletal organization and cell migration. These multiple cellular reactions appear to be mediated by specific receptors which on the outer side of the membrane specifically recognize and bind different components of the extracellular matrix and, on the cytoplasmic side, link a chain of proteins involved in the mechanism of adhesion and cytoskeletal organization (Geiger, 1985).

Keywords

Human Placenta Cytoskeletal Organization Adhesion Plaque Vitronectin Receptor Interference Reflection Microscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Elisabetta Dejana
    • 1
    • 2
  • G. Conforti
    • 1
    • 2
  • A. Zanetti
    • 1
    • 2
  • M. G. Lampugnani
    • 1
    • 2
  • P. C. Marchisio
    • 1
    • 2
  1. 1.Istituto di Ricerche Farmacologiche “Mario Negri”MilanoItaly
  2. 2.Dipartimento di Scienze Biomediche e OncologiaUniversita di TorinoTorinoItaly

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