Advertisement

Response of Vascular Cells to Herpes Simplex Virus Infection

  • Nicholas A. Kefalides
  • Zahra Ziaie

Abstract

Injury to blood vessel cells has been implicated in the development of a variety of vascular disorders including atherosclerosis (Ashford and Freiman, 1968; French, 1966), disseminated intravascular coagulation (Colman et al., 1972) and immune vasculitis (Rosenberg et al., 1971). Endothelial cell injury can arise from a variety of causes including hemodynamic stress (Stemerrnan et al., 1977), hypercholesterolemia (Ross and Harker, 1976), infectious agents (Friedman et al., 1981; Minick et al., 1979; Robbins, 1967), oxygen (Kistler et al., 1976) and other chemical agents such as homocysteine (Wall et al., 1980). Renewed interest in the relationship between vascular injury due to viral infection and atherosclerosis stems from recent observations which demonstrated that virus particles, virus antigens and virus DNA can be detected in vascular lesions of chickens (Fabricant et al., 1978; Minick et al., 1979) and humans (Benditt et al., 1983; Gyorkey et al., 1984; Melnick et al., 1983) with atherosclerosis. Viruses may produce vascular injury by mechanisms other than direct invasion of endothelium. Antigen-antibody complexes involving hepatitis B surface antigen have been isolated from the sera of some patients with periarteritis nodosa (Fye et al., 1977). Tumor formation as a result of viral infection is another possible mechanism by which viruses may induce vascular disease as is the case with cytomegalovirus and Kaposi’s sarcoma (Giraldo et al., 1980).

Keywords

Herpes Simplex Virus Type Infected Culture Endothelial Cell Culture Bovine Endothelial Cell Viral Protein Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashford, T.P. and Freiman, D.G. Platelet aggregation at sites of minimal endothelial injury: an electron microscopic study. Am. J. Pathol 53:599–607, 1968.PubMedGoogle Scholar
  2. Benditt, E.P., Barret, T. and McDougall, J.K. Viruses in the etiology of atherosclerosis. Proc. Natl. Acad. Sci. USA 80:6386–6389, 1983.PubMedCrossRefGoogle Scholar
  3. Brinker, J.M., Ziaie, Z. and Kefalides, N.A. Differential stability of host poly A+ mRNAs in endothelial cells infected with herpes simplex virus type 1. Fed. Proc. 46:1993, 1987.Google Scholar
  4. Cines, D.B., Lyss, A.P., Bina, M., Corkey, R., Kefalides, N.A. and Friedman, H.M. Fc and C3 receptors induced by herpes simplex virus on cultured human endothelial cells. J. Clin. Invest. 69:123–128, 1982.PubMedCrossRefGoogle Scholar
  5. Colman, R.W., Robboy, S.J. and Minna, J.D. Disseminated intra-vascular coagulation (DIC): an approach. Am. J. Med. 52:679–689, 1972.PubMedCrossRefGoogle Scholar
  6. Engvall, E. Enzyme immunoassay elisa and EMIT. Methods Enzymol. 70:419–439, 1980.PubMedCrossRefGoogle Scholar
  7. Fabricant, C.G., Fabricant, J., Litrenta, M.M. and Minick, C.R. Virus-induced atherosclerosis. J. Exp. Med 148:335–340, 1978.PubMedCrossRefGoogle Scholar
  8. Fenwick, M.L. and Clark, J. Early and delayed shut-off of host protein synthesis in cells infected with herpes simplex virus. J.Gen. Virol. 61:121–125, 1982.CrossRefGoogle Scholar
  9. Fenwick and Walker. Suppression of the synthesis of cellular macromolecules by herpes simplex virus. J. Gen. Virol. 41:37–51, 1978.PubMedCrossRefGoogle Scholar
  10. French, J.E. Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to the endothelium. Int. Rev. Exp. Pathol. 5:253–353, 1966.PubMedGoogle Scholar
  11. Friedman, J.M., Macarak, E.J., Macgregor, R.R., Wolfe, J. and Kefalides, N.A. Virus infection of endothelial cells. J. Inf. Dis. 143:266–273, 1981.CrossRefGoogle Scholar
  12. Friedman, J.M., Wolfe, J., Kefalides, N.A. and Macarak, E.J. Susceptibility of endothelial cells derived from different blood vessels to common viruses. In Vitro 22:397–401, 1986.Google Scholar
  13. Fye, K.H., Becker, M.J., Theophilopoulos, A.N., Moutsopoulos, H., Feldman, J. and Talal, N. Immune complexes in hepatitis: antigen associated periarteritis nodosa. Am. J. Med. 62:783–791, 1977.PubMedCrossRefGoogle Scholar
  14. Gimbrone, M.A., Cotran, R.S. and Folkman, J. Human vascular endothelial cells: growth and DNA synthesis. J. Cell Biol. 60:673–684, 1974.PubMedCrossRefGoogle Scholar
  15. Giraldo, G., Beth, E. and Huang, E.S. Kaposi’s sarcoma and its relationship to cytomegalovirus (CMV). Int. J. Cancer 26:23, 1980.PubMedCrossRefGoogle Scholar
  16. Gyorkey, F., Melnick, J.L., Guinn, G.A., Gyorkey, P. and Debakey, M.E. Herpesviridae in the endothelial and smooth muscle cells of the proximal aorta in arteriosclerotic patients. Exp. Mol. Pathol. 40:328–339, 1984.PubMedCrossRefGoogle Scholar
  17. Joklik, W.K. Structure and function of the reovirus genome. Microbiol Rev. 45:483–501, 1981.PubMedGoogle Scholar
  18. Kefalides, M.A. and Ziaie, Z. Herpes simplex virus suppression of human endothelial matrix protein synthesis is independent of viral protein synthesis. Lab. Invest. 55:328–336, 1986.PubMedGoogle Scholar
  19. Kistler, G.S., Caldwell, P.R.G. and Weibal, E.R. Development of fine structural damage to alveolar and capillary lining cells in oxygen poisoned rat lungs. J. Cell Biol. 33:605–628, 1967.CrossRefGoogle Scholar
  20. Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage t4. Nature (London). 227:680–685, 1970.CrossRefGoogle Scholar
  21. Lashgari, M., Friedman, H.M. and Kefalides, N.A. Suppression of matrix protein synthesis by herpes simplex virus in bovine aorta smooth muscle cells. Biochem. Biophys. Res. Commun. 143:145–151, 1987.PubMedCrossRefGoogle Scholar
  22. Macarak, E.J., Howard, B.V. and Kefalides, N.A. Properties of calf endothelial cells in culture. Lab. Invest. 36:62–67, 1977.PubMedGoogle Scholar
  23. Macarak, E.J., Friedman, H.M. and Kefalides, N.A. Herpes simplex virus type 1 infection of endothelium reduces collagen and fibronectin synthesis. Lab Invest. 53:280–286, 1985.PubMedGoogle Scholar
  24. Macgregor, R.R., Friedman, H.M., Macarak, E.J. and Kefalides, N.A. Virus infection of endothelial cells increases granulocyte adherence. J. Clin. Invest. 65:1469–1477, 1980.PubMedCrossRefGoogle Scholar
  25. Melnick, J.L., Petrie, B.L., Dreesman, G.R., Burek, J., McCullum, G.H. and Debakey, M.E. Cytomegalovirus antigen within human arterial smooth muscle cells. Lancet 2:644–647, 1983.PubMedCrossRefGoogle Scholar
  26. Minick, C.R., Fabricant, C.G., Fabricant, J. and Litrenta, M.M. Atheroarteriosclerosis induced by infection with a herpesvirus. Am. J. Pathol. 96:673–706, 1979.PubMedGoogle Scholar
  27. Nishioka, Y. and Silverstein, S. Degradation of cellular mRNA during infection by herpes simplex virus. Proc. Natl. Adac. Sci. USA. 74:2370–2374, 1977.CrossRefGoogle Scholar
  28. Robbins, S.L.. Pathology. pp. 293–294, Saunders, Philadelphia, 1967.Google Scholar
  29. Roizman, B., Borgman, G.S. and Kamali-Rousta, M. Macromolecular synthesis in cells infected with herpes simplex virus. Nature. 206:1374–1375, 1967.CrossRefGoogle Scholar
  30. Rosenberg, J.D., Hawkins, E. and Rector, F. Mechanisms of immunological injury during antibody-mediated hyperacute rejection of renal heterografts. Transplantation. 11:151–157, 1971.PubMedCrossRefGoogle Scholar
  31. Ross, R. and Harker, L. Hyperlipidemia and atherosclerosis: chronic hyperlipidemia initiates and maintains lesions by endothelial cell desquamation and lipid accumulation. Science. 193:1094–1100, 1976.PubMedCrossRefGoogle Scholar
  32. Stemerman, M., Spaet, T.H., Pitlick, F., Cintron, J., Lejnieks, I. and Tiell, M.L. Intimai healing: the pattern of re-endothelialization and intimai thickening. Am. J. Pathol. 87:125–142, 1977.PubMedGoogle Scholar
  33. Sydiskis, R.J. and Roizman, B. The disaggregation of host polysomes in productive and abortive infection with herpes simplex virus. Virology, 32:678–686, 1967.PubMedCrossRefGoogle Scholar
  34. Tumilowicz, J.J., Gawlik, M.E., Powell, B.B. and Trentin, J.J. Replication of cytomegalovirus in human arterial smooth muscle cells. J. Virol. 56:839–845, 1985.PubMedGoogle Scholar
  35. Wall, R.T., Harlan, J.M., Harker, L.A. and Striker, G.E. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb. Res. 18:113–121, 1980.PubMedCrossRefGoogle Scholar
  36. Ziaie, Z. and Kefalides, N.A. Herpes simplex virus (HSV-1) incorporated in the extracellular matrix of HSV-1 infected endothelial cells (EC) influences behavior of freshly seeded EC. Fed Proc. 46:975, 1987.Google Scholar
  37. Ziaie, Z., Friedman, H.M. and Kefalides, N.A. Suppression of matrix protein synthesis by herpes simplex virus type 1 in human endothelial cells. Collagen and Rel. Res. 6:333–350, 1986.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Nicholas A. Kefalides
    • 1
    • 2
  • Zahra Ziaie
    • 1
    • 2
  1. 1.Connective Tissue Research Institute and Department of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.University City Science CenterPhiladelphiaUSA

Personalised recommendations