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Structural Basis for Endothelial Cell Function: Role of Calcium, Polyphosphoinositide Turnover and G-Proteins

  • Una S. Ryan

Abstract

In 1980 it was shown that the vasodilator effect of acetylcholine on the aorta was dependent on an intact endothelium (Furchgott and Zawadski, 1980), later the requirement for intact endothelium was demonstrated for other vasodilator agents, such as bradykinin, ATP, thrombin, and histamine (Furchgott, 1984). In response to these agonists, endothelial cells secrete prostacyclin (PGI2) and endothelium-derived relaxing factor (EDRF) (Furchgott, 1984; Ryan et al., 1988b; Johns et al., 1987; Moncada and Vane, 1978; McIntyre et al., 1985). The latter is closely related to nitric oxide, which has been reported to account for many of its effects (Palmer et al., 1987). Both PGI2, and EDRF cause relaxation of vascular smooth muscle cells and have anti-aggregatory effects on platelets (Furchgott, 1984; Moncada and Vane, 1978; Murray et al., 1986). Some of the same agonists also elicit release of platelet activating factor (PAF) from endothelial cells (Mclntyre et al., 1985), a substance with pro-aggregatory and constrictor actions.

Keywords

Endothelial Cell Cholera Toxin Guanine Nucleotide Pertussis Toxin Inositol Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Una S. Ryan
    • 1
  1. 1.Department of MedicineUniversity of Miami School of MedicineMiamiUSA

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