Receptor Feedback and Dopamine Turnover in CNS

  • Göran Sedvall
Part of the Handbook of Psychopharmacology book series (HBKPS, volume 6)


During the 1960s, histochemical, biochemical, and pharmacological evidence accumulated supporting the existence of specific dopamine (DA) containing neurons in the central nervous system (Carlsson, 1959; Hor-nykiewicz, 1964; Andén et al., 1964a, 1965a). At that time, more than 50 years had elapsed since the chemical synthesis of DA was first described by Mannich and Jacobsohn (1910). Although at an early stage DA was found to exert pharmacological effects on blood pressure and smooth muscle preparations (Barger and Dale, 1910), it was not until 1939 that Blaschko suggested a physiological role for this compound in tissue catecholamine synthesis. In his proposal for the biochemical pathway of catecholamine synthesis, Blaschko suggested DA to be the immediate precursor of norepinephrine. It was not until 1950, however, that McGoodall identified DA as a natural constituent of the heart and the adrenal gland (McGoodall, 1950a,b). Schümann (1956) demonstrated the occurrence of the compound in sympathetic nerves and ganglia. Montague (1957) was the first to present evidence for the presence of DA in the central nervous system. Up to the middle 1950s, DA was thought to play only a precursor role in the biosynthesis of norepinephrine and epinephrine.


Tyrosine Hydroxylase Impulse Activity Homovanillic Acid Corpus Striatum Neuroleptic Drug 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Göran Sedvall
    • 1
  1. 1.Department of PharmacologyKarolinska InstitutetStockholmSweden

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