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Amine Receptors in CNS. I. Norepinephrine

  • Chapter
Biogenic Amine Receptors

Part of the book series: Handbook of Psychopharmacology ((SIBN,volume 6))

Abstract

Among the neurochemicals considered to be candidates for synaptic transmitter function within the central nervous system, the conceptual link to psychopharmacological actions has been particularly strong for norepinephrine (NE). Basic research in psychiatry has concentrated on the changes in brain monoamine metabolism produced by psychoactive drugs (see Snyder, 1974) to develop catecholamine theories of mental diseases. In such a psychopharmacological model, NE is presumed to be a central synaptic transmitter, but the actual functional controls (i.e., excitation or inhibition) exerted by such synapses, their exact cellular location, and their mechanism of action have not been known. This chapter will focus on the methods by which the central receptors for NE may be characterized as to location, function, and pharmacological significance.

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Authors and Affiliations

  1. Laboratory of Neuropharmacology, Division of Special Mental Research, St. Elizabeths Hospital, Washington, D.C., USA

    Floyd E. Bloom

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  1. Floyd E. Bloom
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  1. Department of Pharmacology, University of Cambridge, UK

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, UK

    Susan D. Iversen

  3. Departments of Pharmacology and Psychiatry, School of Medicine, The Johns Hopkins University, USA

    Solomon H. Snyder

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Bloom, F.E. (1975). Amine Receptors in CNS. I. Norepinephrine. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Biogenic Amine Receptors. Handbook of Psychopharmacology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8514-1_1

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