Diabetic Glomerulopathy: A Dynamic Process Produced by the Diabetic Environment

  • M. W. Steffes
  • D. M. Brown
  • S. M. Mauer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 124)


Renal lesions constitute a major factor in the morbidity and mortality of diabetes mellitus; however, the mechanisms underlying the development of diabetic glomerulopathy remain obscure. As a result, the efficacy of current medical management in affecting the development of renal disease in the diabetic population has not been conclusively determined. The central question considers whether diabetic vascular disease exists prior to clinical onset of diabetes or develops solely in relation to the underlying metabolic derangement (Cahill, Etzwiler, and Freinkel, 1976; Siperstein, Foster, Knowles, Levine, Madison, and Roth, 1977). Evidence emphasizing the need to initiate careful control of diabetes in order to alter the development of diabetic glomerulopathy arises from experiments in animals and observations made in man.


Glomerular Basement Membrane Islet Transplantation Diabetic Kidney Renal Plasma Flow Mesangia1 Matrix 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • M. W. Steffes
    • 1
  • D. M. Brown
    • 1
  • S. M. Mauer
    • 1
  1. 1.Departments of Laboratory Medicine and Pathology and PediatricsUniversity of Minnesota Medical SchoolMinneapolisUSA

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