Diabetic Glomerulopathy: A Dynamic Process Produced by the Diabetic Environment
Renal lesions constitute a major factor in the morbidity and mortality of diabetes mellitus; however, the mechanisms underlying the development of diabetic glomerulopathy remain obscure. As a result, the efficacy of current medical management in affecting the development of renal disease in the diabetic population has not been conclusively determined. The central question considers whether diabetic vascular disease exists prior to clinical onset of diabetes or develops solely in relation to the underlying metabolic derangement (Cahill, Etzwiler, and Freinkel, 1976; Siperstein, Foster, Knowles, Levine, Madison, and Roth, 1977). Evidence emphasizing the need to initiate careful control of diabetes in order to alter the development of diabetic glomerulopathy arises from experiments in animals and observations made in man.
KeywordsGlomerular Basement Membrane Islet Transplantation Diabetic Kidney Renal Plasma Flow Mesangia1 Matrix
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- Cahill, G.F. Jr., Etzwiler, D.D., and Freinkel, N. 1976. Blood glucose control in diabetes. Diabetes 25:237–239.Google Scholar
- Hägg, E. 1974. Glomerular basement membrane thickening in rats with long-term diabetes. A quantitative electron microscopic study. Acta. Path. Microbiol. Scand. Sec. A. 82:211–219.Google Scholar
- Østerby, R. 1975. Early phases in the development of diabetic glomerulopathy. Acta. Med. Scand. Suppl. 574:1–80.Google Scholar
- Seyer-Hansen, K. 1976. Renal hypertrophy in streptozotocin-diabetic rats. Clin. Sci. Mol. Med. 51:551–555.Google Scholar