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Somatostatin—Another Pancreatic Islet Hormone

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The Endocrine Pancreas and Juvenile Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 124))

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Abstract

Pancreatic islets contain at least six different types of endocrine cells (Table 1). In most species A, B, and D cells comprise more than 75% of the islet cell mass. A and B cells secrete glucagon and insulin, respectively, and their role in substrate homeostasis is well established. Although D cells were first described shortly after the discovery of A and B cells (Bensley, 1911), much less is known about them and their function. Initially, the D cell was thought to be merely an intermediary

Table 1 Endocrine Cells of Mammalian Islets of Langerhans
Full size table
Table 2 Staining Characteristics of Pancreatic A, B, and D Cells
Full size table

form of A cell due to the poor resolution of A and D cells with stains used to study islet morphology and to the fact that argyrophilic islet cells were mistakenly considered A cells (Takahashi, 1927).

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Authors and Affiliations

  1. Diabetes and Metabolism Research Laboratory, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, MN, 55901, USA

    John E. Gerich

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  1. John E. Gerich
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Editors and Affiliations

  1. University of Missouri - Columbia, Columbia, Missouri, USA

    David M. Klachko , Ralph R. Anderson , Thomas W. Burns  & Harold V. Werner , ,  & 

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© 1979 Plenum Press, New York

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Gerich, J.E. (1979). Somatostatin—Another Pancreatic Islet Hormone. In: Klachko, D.M., Anderson, R.R., Burns, T.W., Werner, H.V. (eds) The Endocrine Pancreas and Juvenile Diabetes. Advances in Experimental Medicine and Biology, vol 124. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8508-0_4

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  • DOI: https://doi.org/10.1007/978-1-4684-8508-0_4

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