Glucagon: Secretion and Actions

  • Mark A. Sperling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 124)


The role of glucagon in normal glucose homeostasis and the potential contribution of this hormone to the genesis and maintenance of the hyperglycemia and ketonemia of diabetes mellitus have been the focus of extensive investigation in the past decade. Recent studies have affirmed the participation and importance of glucagon in the control of hepatic glucose output (Bomboy, Jr., Lewis, Sinclair-Smith, Lacy, and Liljenquist, 1977a; Bomboy, Lewis, Lacy, Sinclair-Smith, and Liljenquist, 1977b; Chiasson, Liljenquist, Jennings, Keller, and Lacy, 1976; Felig, Wahren, and Hendler, 1976a), but at the same time challenged its significance for the genesis of the metabolic abnormalities of diabetes (Felig et al., 1976b). Two major tools have enabled the performance of these studies. The first is the availability of radioimmunoassay procedures utilizing antisera with a high degree of “specificity” for so-called pancreatic glucagon (Sperling, DeLamater, Kazenelson, Fiser, and Fisher, 1974). The second is the availability of somatostatin (SRIF), the tetradecapeptide which inhibits the secretion of a number of hormones including insulin and glucagon (Vale, Brazeau, Rivier, Brown, Boss, Rivier, Burgus, Ling, and Guillemin, 1975).


Growth Hormone Diabetic Ketoacidosis Glucagon Secretion Glucagon Level Plasma Glucagon 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Mark A. Sperling
    • 1
  1. 1.Children’s Hospital Medical Center, Elland and Bethesda AvenuesCincinnatiUSA

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