Advertisement

The Endocrine Pancreas, Past and Present

  • Rachmiel Levine
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 124)

Abstract

Our certain knowledge of the relationship between pancreatic function and diabetes mellitus is roughly 100 years old. However, informed speculation of a possible role played by this gland recurred in the literature periodically from 1787 onward. The story is a fascinating one, full of advances and retreats, faultless logic and foolish errors, but above all serendipity, which finally led to the proven relationship established by Minkowski and Von Mering in 1889.

Keywords

Beta Cell Pancreatic Polypeptide Pancreatic Function Pancreatic Lesion Endocrine Pancreas 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arnozan, C.L. and Vaillard, L. 1884. Contribution a 1’etude de pancreas du lapin. Lesions provoquees par la ligature du canal de Wirsung. Arch. Physiol. Norm. Path. 3(3): 287–316.Google Scholar
  2. Bensley, R.R. 1911–12. Studies on the pancreas of the guinea pig. Amer. J. Anat. 12:297–388.CrossRefGoogle Scholar
  3. Bernard, C. 1856. Memoire sur le pancreas. C.R. Acad. Sci. Paris, Suppl. 1:379–563.Google Scholar
  4. Bouchardat, A. 1852. Du diabete sucre ou glucosurie. Mem. Acad. Med. Paris 16:69–212.Google Scholar
  5. Brisbane, J. 1773. Select cases in the practice of medicine. London: G. Scott. (pp 1–11)Google Scholar
  6. Brisbane, J. 1773. Select cases in the practice of medicine. London: G. Scott. (pp 55–62)Google Scholar
  7. Burger, M. and Kramer, H. 1930. Uber die wirkungsverschiedenheit technischer insuline und kristallisirter preparate bezuglich der primaren insulin hyperglykamie. Arch. Exp. Path. Pharm. 156:1.CrossRefGoogle Scholar
  8. Cawley, T. 1788. A singular case of diabetes, consisting entirely in the quality of the urine; with an inquiry into the different theories of that disease. London Med. J. 9:286–308.Google Scholar
  9. Chevreul, M. E. 1815. Note sur le sucre de diabete. Ann. Chim. Paris 95:319–320.Google Scholar
  10. DeDuve, C. 1945. Glucose, insuline et diabete. Paris: Masson and Cie. (pp XXVII ff and 307)Google Scholar
  11. Diamare, V. 1899. Studii comparativi sulle isole di Langerhans del pancreas. Intern. Mschr. Anat. Physiol. 16:155–209.Google Scholar
  12. Diamare, V. 1924. Documenti per la storia della teoria insulare del diabetes e sui precedenti dell’, insulina. Arch. Fisiol. Florenz 22:141–157.Google Scholar
  13. Dieckhoff, C. 1895. Beitrage zur pathologischen anatomie des Pankreas mit besonderer berucksichtigung der diabetes-frage. Beitrage zur Wiss. Med.: 3–146.Google Scholar
  14. Dobson, M. 1776. Experiments and observations on the urine in diabetes. Med. Obs. Inqui. 5:298–316.Google Scholar
  15. Hedon, E. 1892. Greffe sous-cutanee du pancreas: Ses resultats au point de vue de la theorie du diabetes pancreatique. C.R. Soc. Biol. Paris 44:678–680.Google Scholar
  16. Kimball, C.P. and Murlin, J.R. 1923. Aqueous extracts of pancreas. III. Some precipitation reactions of insulin. J. Biol. Chem. 58:337.Google Scholar
  17. Laguesse, E. 1894. Sur la formation des ilots de Langerhans dans le pancreas. C.R. Soc. Biol. Paris 46:819–820.Google Scholar
  18. Laguesse, E. 1910. Importance des ilots endocrines et de leur cycle evolutif dans la physiologie normale et pathologique du pancreas et particulierement dans le diabete. Presse Med. 18:449–453.Google Scholar
  19. Lancereaux, E. 1877. Notes et reflexions a propos de deux cas de diabete sucre avec alteration du pancreas. Bull. Acad. Med. Paris 6:1215–1240.Google Scholar
  20. Lane, W.A. 1907. The cytological characters of the areas of Langerhans. Amer. J. Anat. 7:409–421.CrossRefGoogle Scholar
  21. Langerhans, P. 1869. Beitrage zur mikroskopischen anatomie der bauchspeicheldruse. Med. Diss. Berlin.Google Scholar
  22. Luft, R., Efendic, S., et al. 1974. Immunohistochernical evidence for localization of somatostatin — immunoreactivity in a cell-population of pancreatic-islets. Med. Biol. 52:428.PubMedGoogle Scholar
  23. Mering, J.V. and Minkowski, O. 1889. Diabetes mellitus nach pankreasexstirpation. Zbl. Klin. Med. 10:393–394.Google Scholar
  24. Meyer, J. 1909. Action de la secretion interne du pancreas sur differents organes et en particulier sur la secretion renale. Arch. Fisiol. 7:96–99.Google Scholar
  25. Minkowski, O. 1893. Untersuchungen uber den diabetes mellitus nach exstirpation des pankreas. Arch. Exp. Path. Pharmak. 31:85–189.CrossRefGoogle Scholar
  26. Minkowski, O. 1929. Die lehre vom pankreas-diabetes in ihrer geschichtlichen entwicklung. Munch. Med. Wschr. 76:311–315.Google Scholar
  27. Orci, L., Amherdt, M., et al. 1977. IN Wasiliewski and Chick (Eds.) Pancreatic beta cell culture. Amsterdam: Excerpta Medica. (p 9 ff)Google Scholar
  28. Rollo, J. 1797. An account of two cases of the diabetes mellitus, with remarks as they arose during the progress of the cure. London: Dilly.Google Scholar
  29. Willis, T. 1674. Pharmaceutice rationalis (Chpt. 3). London.Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Rachmiel Levine
    • 1
  1. 1.City of Hope National Medical CenterDuarteUSA

Personalised recommendations