Advertisement

Ultrastructure of Senile Dementia and of Experimental Analogs

  • Robert D. Terry
  • Henryk M. Wiśniewski
Part of the Advances in Behavioral Biology book series (ABBI, volume 3)

Abstract

The morphologic changes of age which concern the neuropathologist must be not only those he can correlate with clinical signs and symptoms, but also those he can relate to fundamental biology. It is the purpose of this paper to provide as much of this structural correlation as is currently possible in regard to Alzheimer’s disease.

Keywords

Neurofibrillary Tangle Senile Plaque Dense Body Senile Dementia Neurofibrillary Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, R.D., and Sidman, R.L. 1968. Introduction to Neuropathology. New York: The Blakiston Division, McGraw-Hill Book Company, p. 511.Google Scholar
  2. Bensch, K.G.; Marantz, R.; Wisniewski, H. and Shelanski, M. 1969. Induction in vitro of microtubular crystals by vinca alkaloids. Science 165:495.PubMedCrossRefGoogle Scholar
  3. Braunmiihl, A.v. 1957. Alterserkrankungen des Zentralnervensystems. Senile Involution. Senile Demenz. Alzheimersche Krankheit. In Handbuch der Speziellen Pathologischen Anatomie und Histologie, XIII. Part 1. A. Erkrankungen des zentralen Nervensystems 1:337. O. Lubarsch, F. Henke, and R. Rössle (eds.). Berlin: Springer Verlag.Google Scholar
  4. Feldman, R.G.; Chandler, K.A.; Levy, L.L.; and Glaser, G.H. 1963. Familial Alzheimer’s disease. Neurology 13:811.PubMedGoogle Scholar
  5. Glenner, G.G.; Terry, W.; Harada, M.; Isersky, C.; and Page, D. 1971. Amyloid fibril proteins: Proof of homology with immunoglobulin light chains by sequence analyses. Science 172:1150.PubMedCrossRefGoogle Scholar
  6. Gonatas, N.K., and Robbins, E. 1964. The homology of spindle tubules and neuro-tubules in the chick embryo retina. Protoplasma 59:25.Google Scholar
  7. Gonatas, N.K.; Terry, R.D.; and Weiss, M. 1965. Electron microscopic study in two cases of Jakob-Creutzfeldt disease. J. Neuropath. Exp. Neurol. 24:575.PubMedCrossRefGoogle Scholar
  8. Hallgren, B., and Sourander, P. 1960. The non-haemin iron in the cerebral cortex in Alzheimer’s disease. J. Neurochem. 5:307.PubMedCrossRefGoogle Scholar
  9. Hirano, A. 1970. Neurofibrillary changes in conditions related to Alzheimer’s disease. In Ciba Foundation Symposium on Alzheimer’s Disease and Related Conditions. G.E.W. Wolstenholme and M. O’Connor (eds.). London: J. & A. Churchill, p. 185.Google Scholar
  10. Hirano, A.; Dembitzer, H.M.; Kurland, L.T.; and Zimmerman, H.M. 1968. The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and “rod-like” structures as seen in Guam amyotrophic lateral sclerosis and Parkinsonism-Dementia complex. J. Neuropath. Exp. Neurol. 27:167.PubMedCrossRefGoogle Scholar
  11. Karlsson, J.-O.; Hansson, H.-A.; and Sjöstrand, J. 1971. Effect of colchicine on axonal transport and morphology of retinal ganglion cells. Z. Zellforsch. 115:265.PubMedCrossRefGoogle Scholar
  12. Kidd, M. 1963. Paired helical filaments in electron microscopy of Alzheimer’s disease. Nature 197:192.PubMedCrossRefGoogle Scholar
  13. Klatzo, I.; Wisniewski, H.; and Streicher, E. 1965. Experimental production of neurofibrillary degeneration. I. Light microscopic observations. J. Neuropath. Exp. Neurol. 24:187.PubMedCrossRefGoogle Scholar
  14. Krücke, W. 1961. Chronic sclerosing “leucoencephalitis and polyneuritis with intranuclear inclusion bodies”. In Encephalitides. Proceedings of a Symposium on the Neuropathology, Electroencephalography and Biochemistry of Encephalitides, Antwerp 1959. L. Van Bogaert, J. Radermecker, H. Hozay, and A. Lowenthal (eds.). Amsterdam: Elsevier Publishing Company, p. 560.Google Scholar
  15. Marantz, R.; Ventilla, M.; and Shelanski, M. 1969. Vinblastine-induced precipitation of microtubule protein. Science 165:498.PubMedCrossRefGoogle Scholar
  16. Matsuyama, H.; Namiki, H.; and Watanabe, I. 1966. Senile changes in the brain in the Japanese. Incidence of Alzheimer’s neurofibrillary change and senile plaques. In Proceedings of the 5th International Congress of Neuropathology. F. Luthy and A. Bischoff (eds.). Excerpta Medica Series No. 100, p. 979.Google Scholar
  17. Olson, M.I., and Shaw, C.-M. 1969. Presenile dementia and Alzheimer’s disease in mongolism. Brain 92:147.PubMedCrossRefGoogle Scholar
  18. Peterson, E., and Murray, M. 1966. Serial observations in tissue cultures on neurotoxic effects of colchicine. Anat. Rec. 154:401 (abstr.).Google Scholar
  19. Porter, K.R. 1966. Cytoplasmic microtubules and their functions. In Ciba Foundation Symposium on Principles of Biomolecular Organization. G.E.W. Wolstenholme and M. O’Connor (eds.). Boston: Little, Brown, p. 308.Google Scholar
  20. Roth, M.; Tomlinson, B.E.; and Blessed, G. 1966. Correlation between scores for dementia and counts of “senile plaques” in cerebral grey matter of elderly subjects. Nature 209:109.PubMedCrossRefGoogle Scholar
  21. Schochet, S.S., Jr.; Lampert, P.W.; and Earle, K.M. 1968. Neuronal changes induced by intrathecal vincristine sulfate. J. Neuropath. Exp. Neurol. 27:645.PubMedCrossRefGoogle Scholar
  22. Shelanski, M.L.; Liwnicz, B.H.; and Slusarek, W. 1971. Biochemical studies on Guam Parkinsonism Dementia. Trans. Amer. Assoc. Neuropath. San Juan, P.R., June 1971. P. 36.Google Scholar
  23. Shelanski, M.L., and Wisniewski, H. 1969. Neurofibrillary degeneration induced by vincristine therapy. Arch. Neurol 20:199.PubMedCrossRefGoogle Scholar
  24. Suzuki, K., and Terry, R.D. 1967. Fine structural localization of acid phosphatase in senile plaques in Alzheimer’s presenile dementia. Acta Neuropath. 8:276.PubMedCrossRefGoogle Scholar
  25. Terry, R.D. 1963. The fine structure of neurofibrillary tangles in Alzheimer’s disease. J. Neuropath. Exp. Neurol. 22:629.PubMedCrossRefGoogle Scholar
  26. Terry, R.D. 1971. Presidential address. Neuronal fibrous protein in human pathology. J. Neuropath. Exp. Neurol. 30:8.PubMedCrossRefGoogle Scholar
  27. Terry, R.D., Gonatas, N.K.; and Weiss, M. 1964. Ultrastructural studies in Alzheimer’s presenile dementia. Amer. J. Path. 44:269.PubMedGoogle Scholar
  28. Terry, R.D., and Peña, C. 1965. Experimental production of neurofibrillary degeneration. 2. Electron microscopy, phosphatase histochemistry and electron probe analysis. J. Neuropath. Exp. Neurol. 24:200.PubMedCrossRefGoogle Scholar
  29. Terry, R.D., and Wisniewski, H.M. 1970. The ultrastructure of the neurofibrillary tangle and the senile plaque. In Ciba Foundation Symposium on Alzheimer’s Disease and Related Conditions. G.E.W. Wolstenholme and M. O’Connor (eds.). London: J. & A. Churchill, p. 145.Google Scholar
  30. Wisniewski, H.M.; Coblentz, J.M.; and Terry, R.D. 1971. Pick’s disease. A clinical and ultrastructural study. Arch Neurol (in press).Google Scholar
  31. Wisniewski, H.; Johnson, A.B.; Raine, C.S.; Kay, W.J.; and Terry, R.D. 1970. Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study. Lab. Invest. 23:287.PubMedGoogle Scholar
  32. Wisniewski, H.; Shelanski, M.L.; and Terry, R.D. 1968. Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells. J. Cell Biol. 38:224.PubMedCrossRefGoogle Scholar
  33. Wisniewski, H.; and Terry, R.D. 1970. An experimental approach to the morphogenesis of neurofibrillary degeneration and the argyrophilic plaque. In Ciba Foundation Symposium on Alzheimer’s Disease and Related Conditions. G.E.W. Wolstenholme and M.O’Connor (eds.). London: J. & A. Churchill, p. 223.Google Scholar
  34. Wisniewski, H.M.; and Terry, R.D. 1972. Reexamination of the pathogenesis of the senile plaque. In Progress in Neuropathology, vol. 2. H.M. Zimmerman (ed.). New York: Grune & Stratton (in press).Google Scholar
  35. Wisniewski, H.; Terry, R.D.; and Hirano, A. 1970. Neurofibrillary pathology. J. Neuropath. Exp. Neurol. 29:163.PubMedCrossRefGoogle Scholar
  36. Zucker-Franklin, D., and Franklin, E.C. 1970. Intracellular localization of human amyloid by fluorescence and electron microscopy. Amer. J. Path. 59:23.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Robert D. Terry
    • 1
  • Henryk M. Wiśniewski
    • 1
  1. 1.Department of Pathology (Neuropathology)Albert Einstein College of MedicineThe BronxUSA

Personalised recommendations