DNA Repair

  • Mark R. Kelley
  • Leonard C. Erickson


The knowledge of DNA repair and its relation to cancer is expanding at a breathtaking rate.This chapter explores DNA repair and focuses on two of the four main DNA repair pathways: the direct reversal of DNA damage typified by O-6-methylguanine DNA methyltransferase (MGMT, also known as alkylguanine transferase [AGT]) and DNA base excision repair (BER). These two pathways are of particular importance because they have direct implications for the development of experimental therapeutic techniques and gene therapy. The two other pathways, nucleotide excision repair (NER) and mismatch repair (MMR), also are discussed (Table 7–1).


Base Excision Repair MGMT Protein Base Excision Repair Pathway Human MGMT Hematopoietic Stern Cell 
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© Current Medicine, Inc. 2000

Authors and Affiliations

  • Mark R. Kelley
  • Leonard C. Erickson

There are no affiliations available

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