Mitogenic Signal Transduction

  • Jonathan Chernoff


The ability to sense and respond to environmental signals is fundamental to the development and survival of all organisms. At the cellular level, external cues such as temperature, osmotic pressure, presence or absence of nutrients, and presence or absence of specific hormones or growth factors are continuously monitored. The process of perceiving and responding to such signals is termed signal transduction.


Adaptor Protein Pleckstrin Homology Domain Receptor Protein Tyrosine Kinase Phosphorylated Tyrosine Residue Phosphotyrosine Binding 
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  1. 1.
    Assoian RK, Zhu X: Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression. Curr Opin Cell Biol 1997, 9: 93–98.PubMedCrossRefGoogle Scholar
  2. 2.
    Giancotti FG: Integrin signaling: specificity and control of cell survival and cell cycle progression. Curr Opin Cell Biol 1998, 9: 691–700.CrossRefGoogle Scholar
  3. 3.
    van der Geer P, Hunter T, Lindberg RA: Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 1994, 10: 251–337.PubMedCrossRefGoogle Scholar
  4. 4.
    Post GR, Brown JH: G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J 1996, 10: 741–749.PubMedGoogle Scholar
  5. 5.
    Heldin C-H: Dimerization of cell surface receptors in signal transduction. Cell 1995, 80: 213–223.PubMedCrossRefGoogle Scholar
  6. Sonyang Z, Shoelson SE, Chaudhuri M, et al SH2 domains recognize specific phosphopeptide sequences. Cell 1993, 72:767–778.Google Scholar
  7. 7.
    Pawson T: Protein modules and signalling networks. Nature 1995, 373: 573–579.PubMedCrossRefGoogle Scholar
  8. 8.
    Pawson T, Scott JD: Signaling through scaffold, anchoring, and adaptor proteins. Science 1997, 278: 2075–2080.PubMedCrossRefGoogle Scholar
  9. 9.
    Fruman DA, Meyers RE, Cantley LC: Phosphoinositide kinases. Annu Rev Biochem 1998, 67: 481–507.PubMedCrossRefGoogle Scholar
  10. 10.
    Kamat A, Carpenter G: Phospholipase C-gammal: regulation of enzyme function and role in growth factor—dependent signal transduction. Cytokine Growth Factor Rev 1997, 8: 109–117.PubMedCrossRefGoogle Scholar
  11. 11.
    Strum JC, Ghosh S, Bell RM: Lipid second messengers: a role in cell growth regulation and cell cycle progression. Adv Exp Med Biol 1997, 407: 421–431.PubMedGoogle Scholar
  12. Li N, Batzer A, Daly R, et al Guanine-nucleotide-releas- ing factor hSos1 binds to Grb2 and links receptor tyro- sine kinases to Ras signaling. Nature 1993, 363:85–88.Google Scholar
  13. 13.
    Schlessinger J: SH2/SH3 signaling proteins. Curr Opin Genet Dey 1994, 4: 25–30.CrossRefGoogle Scholar
  14. 14.
    Gutkind JS: The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998, 273: 1839–1842.PubMedCrossRefGoogle Scholar
  15. Macara IG, Lounsbury KM, Richards SA, et al The Ras superfamily of GTPases. FASEB J 1996, 10:625–630.Google Scholar
  16. 16.
    Bos JL: Ras oncogenesis in human cancer: a review. Cancer Res 1989, 49: 4682–4689.PubMedGoogle Scholar
  17. Kohl NE, Mosser SD, deSolms SJ, et al Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 1993, 260:1934–1937.Google Scholar
  18. 18.
    Katz ME, McCormick F: Signal transduction from multiple Ras effectors. Curr Opin Genet Dey 1997, 7: 75–79.CrossRefGoogle Scholar
  19. 19.
    Vojtek AB, Der CJ: Increasing complexity of the Ras signaling pathway. J Biol Chem 1998, 273: 19925–19928.PubMedCrossRefGoogle Scholar
  20. White MA, Nicolette C, Minden A, et al Multiple Ras functions can contribute to mammalian cell transformation. Cell 1995, 80:533–541.Google Scholar
  21. 21.
    Joneson T, Bar-Sagi D: Ras effectors and their role in mitogenesis and oncogenesis. J Mol Med 1997, 75: 587–593.PubMedCrossRefGoogle Scholar
  22. 22.
    Hall A: Rho GTPases and the actin cytoskeleton. Science 1998, 279: 509–514.PubMedCrossRefGoogle Scholar
  23. 23.
    Marshall M: Interactions between Ras and Raf: key regulatory proteins in cellular transformation. Mol Reprod Dey 1995, 42: 493–499.CrossRefGoogle Scholar
  24. Whitmarsh AJ, Cavanagh J, Tournier C, et al A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 1998, 281:1671–1674.Google Scholar
  25. Schaeffer HJ, Catling AD, Eblen ST, et al MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 1998, 281:1668–1671.Google Scholar
  26. 26.
    Robinson MJ, Cobb MH: Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997, 9: 180–186.PubMedCrossRefGoogle Scholar
  27. 27.
    Brunet A, Pouyssegur J: Mammalian MAP kinase modules: how to transduce specific signals. Essays Biochem 1997, 32: 1–16.PubMedGoogle Scholar
  28. 28.
    Waskiewicz AJ, Cooper JA: Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol 1995, 7: 798–805.PubMedCrossRefGoogle Scholar
  29. 29.
    Karin M, Hunter T: Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol 1995, 5: 747–757.PubMedCrossRefGoogle Scholar
  30. 30.
    Karin M: The regulation of AP-1 activity by mitogenactivated protein kinases. J Biol Chem 1995, 270: 16483–16486.PubMedGoogle Scholar
  31. 31.
    Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate. J Biol Chem 1998, 273: 13375–13378.PubMedCrossRefGoogle Scholar
  32. 32.
    Woscholski R, Parker PJ: Inositol lipid 5-phosphatases: tRaffic signals and signal tRaffic.Trends Biochem 1997, 22: 427–431.Google Scholar
  33. 33.
    McCormick F: Ras signaling and NF1. Curr Opin Genet Dey 1995, 5: 51–55.CrossRefGoogle Scholar
  34. 34.
    Keyse SM: Protein phosphatases and the regulation of MAP kinase activity. Semin Cell Dey Biol 1998, 9: 143–152.CrossRefGoogle Scholar
  35. 35.
    Massagué J: TGF-beta signal transduction. Annu Rev Biochem 1998, 67: 753–791.PubMedCrossRefGoogle Scholar

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© Current Medicine, Inc. 2000

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  • Jonathan Chernoff

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