Protease Nexin I Immunostaining in Alzheimer’s Disease
The NATO Conference which provided the impetus for this book was focused on protease and protease inhibitor activity in the nervous system. The conference covered both the Peripheral Nervous System (PNS) and the Central Nervous System (CNS) and addressed both developmental and pathological conditions. A recurrent theme throughout the conference was that of a crucial balance between proteolytic enzyme and inhibitor activity. Another theme of the conference was that of neuron-glia interaction. This chapter will report on immunohistochemical studies on Protease Nexin I (PN I), a glial-derived serine protease inhibitor with neurite promoting activity, in Alzheimer brain and will discuss the results in light of material presented at the conference.
KeywordsHeparan Sulfate Alzheimer Brain Neuritic Plaque Protease Inhibitor Activity Protease Complex
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