Protease Nexin I Immunostaining in Alzheimer’s Disease

  • Dorrie E. Rosenblatt
  • Changiz Geula
  • Marsel-Marek Mesulam
Part of the NATO ASI Series book series (NSSA, volume 191)


The NATO Conference which provided the impetus for this book was focused on protease and protease inhibitor activity in the nervous system. The conference covered both the Peripheral Nervous System (PNS) and the Central Nervous System (CNS) and addressed both developmental and pathological conditions. A recurrent theme throughout the conference was that of a crucial balance between proteolytic enzyme and inhibitor activity. Another theme of the conference was that of neuron-glia interaction. This chapter will report on immunohistochemical studies on Protease Nexin I (PN I), a glial-derived serine protease inhibitor with neurite promoting activity, in Alzheimer brain and will discuss the results in light of material presented at the conference.


Heparan Sulfate Alzheimer Brain Neuritic Plaque Protease Inhibitor Activity Protease Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Dorrie E. Rosenblatt
    • 1
  • Changiz Geula
    • 2
  • Marsel-Marek Mesulam
    • 2
  1. 1.lnstitute of Gerontology & Div. of GeriatricsUniversity of MichiganUSA
  2. 2.Division of Neuroscience & Behavioral NeurologyHarvard Medical SchoolUSA

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