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Serine Proteases and Their Serpin Inhibitors in the Nervous System pp 21–30Cite as

A Key Molecule Dictating and Regulating Surface Plasmin Formation : The Receptor for Urokinase Plasminogen Activator

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Part of the book series: NATO ASI Series ((NSSA,volume 191))

Abstract

Regulation of cell to cell contacts and of cell migration is thought to require the action of protease systems which are needed to sever the ties that link cells to other cells and to the extracellular matrix, and to overcome barriers like the basement membranes. Since cell migration phenomena occur from gametogenesis through embryonic development to adulthood, and since also many pathological disorders are associated with or require tissue destruction and cell migration, the requirement for extracellular proteolytic enzymes is a very widespread phenomenon, which however has not yet been clearly understood on a molecular biological and biochemical basis.1–3

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Authors and Affiliations

  1. Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark

    Niels Behrendt, Vincent Ellis & Keld Danø

  2. Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, USA

    Ettore Appella

  3. Institute of Microbiology, University of Copenhagen, Øster Farimagsgade 2A, 1353, Copenhagen K, Denmark

    Francesco Blasi, M. Vittoria Cubellis, Ann Louring Roldan & Maria Teresa Masucci

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  1. Francesco Blasi
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  2. M. Vittoria Cubellis
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  4. Maria Teresa Masucci
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  5. Niels Behrendt
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  6. Vincent Ellis
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  7. Ettore Appella
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Editors and Affiliations

  1. Veterans Administration Medical Center, University of Kansas Medical Center, 64128, Kansas City, Missouri, USA

    Barry W. Festoff M.D. (Director) (Director)

  2. I.N.S.E.R.M., Unité 153, 75005, Paris, France

    Daniel Hantaï M.D., Ph.D.

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Blasi, F. et al. (1990). A Key Molecule Dictating and Regulating Surface Plasmin Formation : The Receptor for Urokinase Plasminogen Activator. In: Festoff, B.W., Hantaï, D. (eds) Serine Proteases and Their Serpin Inhibitors in the Nervous System. NATO ASI Series, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8357-4_3

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