The Serpin, α1-Antichymotrypsin, in Brain Aging and Diseases of the Nervous System
One of the main neuropathological lesions that characterize the brains of Alzheimer disease patients is the neuritic or senile plaque, which consists of a spherical core of extracellular protein filaments surrounded by a halo of degenerating nerve cell processes. Extracellular protein filaments similar to those in the cores of neuritic plaques also occur in the walls of meningeal and intracortical blood vessels. The proteinaceous deposits in the cores of neuritic plaques and in blood vessels are referred to by the generic term “amyloid” generally defined as an aggregate of extacellular 6–10 nm protein filaments that has certain tinctorial properties.
KeywordsAmyloid Deposit Cerebral Amyloid Angiopathy Neuritic Plaque Amyloid Protein Alzheimer Disease Patient
Unable to display preview. Download preview PDF.
- 1.G.G. Glenner, and C.W. Wong, Alzheimer’s disease-initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 122: 885–890 (1984).Google Scholar
- 2.C.L. Masters, G. Multhaup, G. Simms, J. Pottgieser, R.N. Martins, and K. Beyreuther, Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer’s disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J. 4: 2757 (1985).Google Scholar
- 10.H.M. Wisniewski, and R.D. Terry, Morphology of the aging brain, human and animal. In: Progress in Brain Research, 1973; Vol. 40, Neurobiological Aspects of Maturation and Aging ed. D.H. Ford, pp. 1108–1109. Amsterdam: Elsevier.Google Scholar
- 14.M. Tomonoga, Cerebral amyloid angiopathy in the elderly. J. Amer. Geriatr. Soc. 29: 151–157 (1981).Google Scholar
- 15.C.L. Joachim, L.K. Duffy, J. Morris, and D.J. Selkoe, Protein chemical and immunocytochemical studies of meningovascular p-amyloid protein in Alzheimer’s disease and normal aging. Brain Res., 474: 100–111 (1988).Google Scholar
- 16.A. Weidemann, G. König, D. Bunke, P. Fischer, C.L. Masters, and K. Beyreuther, Identification, biogenesis and localization of precursors of Alzheimer’s disease A4 amyloid protein. Cell 57: 115126 (1989).Google Scholar
- 26.H. Baumann, C. Richards, and J. Gauldie, Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J. Immunol. 139: 4122–4128 (1987).Google Scholar