Serpins and Brain Tumors: Roles in Pathogenesis
Brain tumors constitute a group of heterogeneous neoplasms. Pathophysiological mechanisms associated with the neoplastic process involve a complex balance of fibrinolytic and coagulation enzymes. The fibrinolytic enzyme system covers a wide spectrum ranging from tumor growth to tumor invasiveness, tumor hemorrhage and tumor host interactions leading to serious coagulopathies and thromboembolic complications.1–4 The primary malignant brain tumors are also rich in fibrinolytic activity and are recognized for their low potential to metastasize, while they invade locally. The low potentiality of brain tumors to metastasize may be due to behavior of enzymes and the overproduction of inhibitors. Tumor spread correlates directly with tumor activation of fibrinolysis and inversely with inhibitors of fibrinolysis. Both proteolysis and anti-proteolytic activity have been associated with primary brain malignancies.
KeywordsConditioned Medium Human Brain Tumor Fibrin Plate Protease Nexin Reverse Zymography
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