Steps in Establishing a Biological Relevance for Glia-Derived Nexin
The development and maintenance of the nervous system requires a multiplicity of interactions between the neuroblast and the neuron and their respective environments. After a phase of cellular migration, the first step in the differentiation program of the neuroblast is to extend neurites which will become either dendrites capable of receiving information from the afferent cells or axons which will establish contact with specific targets in order to propagate this information. Today, neurite outgrowth is considered to be a complex phenomenon which can be influenced by many different molecules. Neurotrophic factors, neurotransmitters, and components of the extracellular matrix trigger or modulate this event in vitro and, in some cases, in vivo.1–6 Some of the same molecules are probably also involved in the regenerative events whereby neurite outgrowth is reinitiated following a lesion.
KeywordsNerve Growth Factor Sciatic Nerve Neurite Outgrowth Olfactory System Promote Neurite Outgrowth
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