Abstract
A variety of fundamental regulatory processes seems to be dependent upon short-range cellular interactions with immediate neighbors, and with the organized structural scaffolding of the extracellular matrix (ECM). These interactions contribute to the maintenance and repair of tissue organization in adult animals, and appear to be particularly important for conveying the positional information that is essential for the control of cellular migration, proliferation and differentiation during embryo-genesis. While all of these processes can be inhuenced by exogenous humoral factors, and by the adhesive substances of the ECM, it is not yet clear how the relevant regulatory signals are generated and distinguished at appropriate sites of close cell contact in vivo (for reviews, see references 1–3). Our ignorance stems primarily from the fact that the most striking ‘inductive’ cellular interactions occur only transiently, at discrete sites within intact living organisms, a situation which restricts the use of conventional biochemical methods. If these limitations could be overcome by cytochemical techniques, therefore, it should become possible to determine the sequence of biochemical events that are initiated during inductive interactions between individual cell-pairs, and perhaps to identify the key molecular events that are most directly affected by close cell contact.
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Anderson, M.J., Swenarchuk, L.E., Champaneria, S. (1990). Localized Extracellular Proteolysis May Convey Inductive Signals Between Nerve and Muscle Cells During Synaptogenesis. In: Festoff, B.W., Hantaï, D. (eds) Serine Proteases and Their Serpin Inhibitors in the Nervous System. NATO ASI Series, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8357-4_23
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DOI: https://doi.org/10.1007/978-1-4684-8357-4_23
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