Relationship Between Plasminogen Activators and Regeneration Capacities of Rat Skeletal Muscles

  • Georgia Barlovatz-Meimon
  • Éric Frisdal
  • Yann Bassaglia
  • Daniel Hantaï
  • Eduardo Anglés-Cano
  • Jean Gautron
Part of the NATO ASI Series book series (NSSA, volume 191)


Mammalian skeletal muscle regeneration may be divided in two major parts. The first is a degenerative period leading to muscle atrophy as a result of the catabolic conditions due to tissue breakdown, cell death, and subsequent presence of large amounts of lysosomal and non lysosomal proteinases.1,2 The second step is characterized by tissue remodelling resulting in a relatively complete regeneration.3–8 This step was described by Bischoff 9 as dependent upon the capacity of neutral proteinases to digest the basement membrane. It involves changes in the amount and distribution of various components of the basement membrane10 such as fibronectin2, laminin and type IV collagen.12,13 The participation of the plasminogen activator (PA) system in these modifications has been described.14 In addition, a large amount of information links tissue remodelling to the activity of serine proteinases such as PAs.15


Plasminogen Activator Satellite Cell Extensor Digitonlm Longus Muscle Regeneration Myogenic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Georgia Barlovatz-Meimon
    • 1
  • Éric Frisdal
    • 1
  • Yann Bassaglia
    • 1
  • Daniel Hantaï
    • 2
  • Eduardo Anglés-Cano
    • 3
  • Jean Gautron
    • 1
  1. 1.MYREM, Université Paris XIICréteilFrance
  2. 2.INSERM U.153ParisFrance
  3. 3.INSERM U.143Le Kremlin-BicêtreFrance

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