Glial Plasminogen Activators in Developing and Regenerating Neural Tissue

  • Nurit Kalderon
Part of the NATO ASI Series book series (NSSA, volume 191)


In the following chapter I would like to introduce the postulate that a population of neural cells -- the glia -- serve as construction/remodelling agents in morphogenetic processes during development and regeneration of the nervous system. The capacity of these glial cells to perform their plasticity function effectively is dependent on their potential to generate extracellular proteolytic activities, namely, to produce plasminogen activator (PA) of the urokinase type (u-PA). Previously published and new data are being presented in support of this hypothesis.


Sciatic Nerve Schwann Cell Peripheral Nerve Regeneration Nerve Stump Plasmin Activity 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Nurit Kalderon
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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