Multiple Roles for Plasminogen Activator System in Nervous System Development
Brain development involves several steps where extracellular proteolytic activities are required, either in intercellular signalling or in tissue remodeling. Those proteolytic activities are in part due to plasminogen activators (PA) which are released by cells of the nervous system and have been implicated in several aspects of neuronal and glial biology. Both forms of PA, the urokinase type (uPA) and the tissue type (tPA) are produced by various cell populations of the mammalian nervous system. Their production appears to be developmentally regulated, being most prominent at various stages of neuronal or glial cells ontogenesis in the embryo or soon after birth.
KeywordsPC12 Cell Nerve Growth Factor Plasminogen Activator Schwann Cell Neuritic Outgrowth
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