Evolutionary Adaptations of Serpins and their Use in Designing New Proteinase Inhibitors
Human plasma contains a myriad of proteins with specialized functions. Of these, proteinase inhibitors represent 10% of the total protein and can be classified as the third major group in this fluid, after albumin and the immunoglobulins. Their functions are to regulate proteolytic enzymes which are normally utilized in coagulation, fibrinolysis, complement activation, phagocytosis, etc. Thus, since these processes involve a variety of proteinases with vastly different specificities it is only logical that specific inhibitors must also be utilized to regulated each system on an individual basis.
KeywordsReactive Site Neutrophil Elastase Human Neutrophil Elastase Elastase Inhibitor Inhibitor Secretion
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