Evolutionary Adaptations of Serpins and their Use in Designing New Proteinase Inhibitors

  • Jan Potempa
  • Bie-Hue Shieh
  • Amelia Guzdek
  • Adam Dubin
  • Amy Colquhoun
  • James Travis
Part of the NATO ASI Series book series (NSSA, volume 191)


Human plasma contains a myriad of proteins with specialized functions. Of these, proteinase inhibitors represent 10% of the total protein and can be classified as the third major group in this fluid, after albumin and the immunoglobulins. Their functions are to regulate proteolytic enzymes which are normally utilized in coagulation, fibrinolysis, complement activation, phagocytosis, etc. Thus, since these processes involve a variety of proteinases with vastly different specificities it is only logical that specific inhibitors must also be utilized to regulated each system on an individual basis.


Reactive Site Neutrophil Elastase Human Neutrophil Elastase Elastase Inhibitor Inhibitor Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jan Potempa
    • 1
  • Bie-Hue Shieh
    • 1
  • Amelia Guzdek
    • 1
  • Adam Dubin
    • 1
  • Amy Colquhoun
    • 1
  • James Travis
    • 1
  1. 1.Dept. of BiochemistryUniversity of GeorgiaAthensUSA

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