Thrombin Structural Regions in Determining Bioregulatory Functions

  • John W. FentonII
Part of the NATO ASI Series book series (NSSA, volume 191)


Thrombin (EC is the activation product of its blood-circulating or cellular-sequestered zymogen, prothrombin. Unlike the majority of enzymes and activated proteins of the blood-coagulation, fibrinolytic, and complement systems, thrombin has multiple bioregulatory functions, which are central in hemostasis, wound healing, and perhaps developmental, as well as certain disease processes.1–6


Thrombin Generation Factor Xiii Bovine Thrombin Human Thrombin Form Alone 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • John W. FentonII
    • 1
    • 2
  1. 1.Wadsworth Center for Laboratories & Research, New York State Department of HealthEmpire State PlazaAlbanyUSA
  2. 2.Department of PhysiologyThe Albany Medical College of Union UniversityAlbanyUSA

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