Advertisement

The Prediction of Drug Activity

  • R. B. Barlow

Abstract

If the biological effects of a drug depend on some physical action on cells it would seem obvious that it should be possible to predict its biological activity from its physical properties. A biological effect is only known to be nonspecific, however, when it has been shown to be independent of chemical structure, so the prediction of activity is rather an extrapolation from what is already known than a prediction of something completely new. It may, nevertheless, be useful to know how to make drugs which are more active.

Keywords

Partition Coefficient British Journal Phenyl Group Quantitative Aspect Apparent Molal Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    K. H. Meyer and H. Hemmi, Biochim. Z. (1935), no. 277, p. 39.Google Scholar
  2. 2.
    J. Ferguson, Proc. Roy. Soc., B (1939), no. 127, p. 387.Google Scholar
  3. 3.
    A. Frumkin, Z. Physik. Chim. (1925), no. 116, p. 501; R. Collander, Acta Physiol. Scand. (1947), no. 13, p. 363.Google Scholar
  4. 4.
    R. Collander, Acta Chem. Scand. (1954), no. 5, p. 774.CrossRefGoogle Scholar
  5. 5.
    C. Hansch, P. P. Maloney, T. Fujita and R. M. Muir, Nature (1962), no. 194, p. 178.CrossRefGoogle Scholar
  6. 6.
    Hansch, R. M. Muir, T. Fujita, P. P. Maloney, F. Geiger and M. Streich, Journal American Chem. Soc. (1963), no. 85, p. 2817.CrossRefGoogle Scholar
  7. 7.
    C. Hansch and T. Fujita, Journal American Chem. Soc. (1964), no. 86, p. 1616.CrossRefGoogle Scholar
  8. 8.
    J. Iwasa, T. Fujita and C. Hansch, Journal Med. Chem. (1965), no. 8, p. 150.CrossRefGoogle Scholar
  9. 9.
    C. Hansch and S. M. Anderson, Journal Med. Chem. (1967), no. 10, p. 745.CrossRefGoogle Scholar
  10. C. Hansch, A. R. Steward, J. Iwasa and E. W. Deutsch, Mol. Pharmacol. (1965), no. 1, p. 205; C. Hansch, A. R. Steward, S. M. Anderson and D. Bentley, Journal Med. Chem. (1968), no. 11, p. 1.Google Scholar
  11. 11.
    M. S. Tute, in Advances in Drug Research, N. J. Harper and A. B. Simmonds (eds.) ( Academic Press, New York, 1971 ), p. 1.Google Scholar
  12. 12.
    C. Hansch, in Chemical Structure and Biological Activity, J. A. Keverling Buisman (ed.) (Elsevier, Amsterdam, 1977), p. 47, p. 292.Google Scholar
  13. 13.
    R. B. Barlow, K. A. Scott and R. P. Stephenson, British Journal Pharmacol. (1963), no. 21, p. 509.Google Scholar
  14. 14.
    S. M. Free and J. W. Wilson, Journal Med. Chem. (1964), no. 7, p. 395.CrossRefGoogle Scholar
  15. 15.
    F. B. Abramson, R. B. Barlow, M. G. Mustafa and R. P. Stephenson, British Journal Pharmacol. (1969), no. 37, p. 207.Google Scholar
  16. 16.
    F. B. Abramson, R. B. Barlow, F. M. Franks and J. D. M. Pearson, British Journal Pharmacol. (1974), no. 51, p. 81.Google Scholar
  17. 17.
    R. B. Barlow, F. M. Franks and J. D. M. Pearson, Journal Med. Chem. (1973), no. 16, p. 439.CrossRefGoogle Scholar
  18. 18.
    B. Belleau, H. Tani and F. Lie, Journal American Chem. Soc. (1965), no. 87, p. 2283.CrossRefGoogle Scholar
  19. 19.
    B. Belleau and J. L. Lavoie, Canadian Journal Biochem. (1968), no. 46, p. 1397.CrossRefGoogle Scholar
  20. 20.
    B. Belleau, Journal Med. Chem. (1964), no. 7, p. 776; Ann. NY Acad. Sci. (1967), no. 144, p. 705; in Physicochemical Aspects of Drug Action, E. J. Ariens (ed.) ( Pergamon, Oxford, 1968 ), p. 207.Google Scholar
  21. 21.
    R. B. Barlow, K. J. Berry, P. A. M. Glenton, N. M. Nikolaou and K. S. Soh, British Journal Pharmacol. (1976), no. 58, p. 613.Google Scholar
  22. 22.
    E. W. Gill, in Progress in Medicinal Chemistry, vol. 4, G. P. Ellis and G. B. West (eds.) (Butterworth, London, 1965 ), p. 39.Google Scholar
  23. 23.
    C. Tanford, The Hydrophobic Effect (Wiley, New York, 1973); F. Franks, in Water, A Comprehensive Treatise, vol. 4 (Plenum Press, New York, 1975), p. 1; A. Suggett, in Biological Activity and Chemical Structure, J. A. Keverling Buisman (ed.) ( Elsevier, Amsterdam, 1977 ), p. 95.Google Scholar
  24. 24.
    L. Pauling, The Chemical Bond (Cornell University Press, Ithaca, 1967 ), p. 228; J. C. Speakman, The Hydrogen Bond ( Chemical Society, London, 1975 ).Google Scholar
  25. 25.
    S. Arnott, M. H. F. Wilkins, L. D. Hamilton and R. Langridge, Journal Mol. Biol. (1965), no. 11, p. 391.CrossRefGoogle Scholar
  26. 26.
    R. B. Barlow and J. H. Tubby, British Journal Pharmacol. (1974), no. 51, p. 95.Google Scholar
  27. 27.
    D. D. Woods, British Journal Exp. Path. (1940), no. 21, p. 74.Google Scholar
  28. 28.
    P. Fildes, Lancet (1940), no. i, p. 955.Google Scholar
  29. 29.
    A. J. Clark, The Mode of Action of Drugs on Cells ( Arnold, London, 1933 ).Google Scholar
  30. 30.
    A. J. Clark, Handbuch der Experimentellen Pharmakologie, IV (Springer, Berlin, 1937) (in English, reprinted 1973 ).Google Scholar

Copyright information

© R.B. Barlow 1980

Authors and Affiliations

  • R. B. Barlow
    • 1
  1. 1.University of BristolUK

Personalised recommendations